Tuesday, June 25, 2013

Helping RNA escape from cells' recycling process could make it easier to shut off disease-causing genes

June 24, 2013 ? Nanoparticles that deliver short strands of RNA offer a way to treat cancer and other diseases by shutting off malfunctioning genes. Although this approach has shown some promise, scientists are still not sure exactly what happens to the nanoparticles once they get inside their target cells.

A new study from MIT sheds light on the nanoparticles' fate and suggests new ways to maximize delivery of the RNA strands they are carrying, known as short interfering RNA (siRNA).

"We've been able to develop nanoparticles that can deliver payloads into cells, but we didn't really understand how they do it," says Daniel Anderson, the Samuel Goldblith Associate Professor of Chemical Engineering at MIT. "Once you know how it works, there's potential that you can tinker with the system and make it work better."

Anderson, a member of MIT's Koch Institute for Integrative Cancer Research and MIT's Institute for Medical Engineering and Science, is the leader of a research team that set out to examine how the nanoparticles and their drug payloads are processed at a cellular and subcellular level. Their findings appear in the June 23 issue of Nature Biotechnology. Robert Langer, the David H. Koch Institute Professor at MIT, is also an author of the paper.

One RNA-delivery approach that has shown particular promise is packaging the strands with a lipidlike material; similar particles are now in clinical development for liver cancer and other diseases.

Through a process called RNA interference, siRNA targets messenger RNA (mRNA), which carries genetic instructions from a cell's DNA to the rest of the cell. When siRNA binds to mRNA, the message carried by that mRNA is destroyed. Exploiting that process could allow scientists to turn off genes that allow cancer cells to grow unchecked.

Scientists already knew that siRNA-carrying nanoparticles enter cells through a process, called endocytosis, by which cells engulf large molecules. The MIT team found that once the nanoparticles enter cells they become trapped in bubbles known as endocytic vesicles. This prevents most of the siRNA from reaching its target mRNA, which is located in the cell's cytosol (the main body of the cell).

This happens even with the most effective siRNA delivery materials, suggesting that there is a lot of room to improve the delivery rate, Anderson says.

"We believe that these particles can be made more efficient. They're already very efficient, to the point where micrograms of drug per kilogram of animal can work, but these types of studies give us clues as to how to improve performance," Anderson says.

Molecular traffic jam

The researchers found that once cells absorb the lipid-RNA nanoparticles, they are broken down within about an hour and excreted from the cells.

They also identified a protein called Niemann Pick type C1 (NPC1) as one of the major factors in the nanoparticle-recycling process. Without this protein, the particles could not be excreted from the cells, giving the siRNA more time to reach its targets. "In the absence of the NPC1, there's a traffic jam, and siRNA gets more time to escape from that traffic jam because there is a backlog," says Gaurav Sahay, an MIT postdoc and lead author of the Nature Biotechnology paper.

In studies of cells grown in the lab without NPC1, the researchers found that the level of gene silencing achieved with RNA interference was 10 to 15 times greater than that in normal cells.

Lack of NPC1 also causes a rare lysosomal storage disorder that is usually fatal in childhood. The findings suggest that patients with this disorder might benefit greatly from potential RNA interference therapy delivered by this type of nanoparticle, the researchers say. They are now planning to study the effects of knocking out the NPC1 gene on siRNA delivery in animals, with an eye toward testing possible siRNA treatments for the disorder.

The researchers are also looking for other factors involved in nanoparticle recycling that could make good targets for possibly slowing down or blocking the recycling process, which they believe could help make RNA interference drugs much more potent. Possible ways to do that could include giving a drug that interferes with nanoparticle recycling, or creating nanoparticle materials that can more effectively evade the recycling process.

The research was funded by Alnylam Pharmaceuticals and the National Heart, Lung, and Blood Institute.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/7V-2JNR49qM/130624144824.htm

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Monday, June 24, 2013

Federer begins quest for 8th Wimbledon title

LONDON (AP) ? As he has six previous times, Roger Federer will begin Wimbledon on Monday as the defending champion. When he steps onto Centre Court he hopes it will be the start of another two-week stay at the All England Club.

It's an honor reserved for the men's titleholder. That scheduling perk is also where any hint of preferential treatment for Federer comes to a halt. Because of the way the draw came out, Federer could have to defeat Rafael Nadal and Andy Murray before even getting to the final.

Federer said Sunday he's "ready for the challenge" and he doesn't shy away from "tough draws."

His quest for a record eighth Wimbledon title begins against 47th-ranked Victor Hanescu of Romania.

Source: http://news.yahoo.com/federer-begins-quest-8th-wimbledon-title-170614576.html

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South Africa: Nelson Mandela in critical condition

JOHANNESBURG (AP) ? Nelson Mandela's health has deteriorated and he is now in critical condition, the South African government said Sunday.

The office of President Jacob Zuma said in a statement that he had visited the 94-year-old anti-apartheid leader at a hospital Sunday evening and was informed by the medical team that Mandela's condition had become critical in the past 24 hours.

"The doctors are doing everything possible to get his condition to improve and are ensuring that Madiba is well-looked after and is comfortable. He is in good hands," Zuma said in the statement, using Mandela's clan name.

Zuma also met Graca Machel, Mandela's wife, at the hospital in Pretoria and discussed the former leader's condition, according to the statement. Zuma was accompanied on the visit by Cyril Ramaphosa, the deputy president of the country's ruling party, the African National Congress.

Mandela was jailed for 27 years under white racist rule and released in 1990. He then played a leading role in steering the divided country from the apartheid era to democracy, becoming South Africa's first black president in all-race elections in 1994. He was hospitalized on June 8 for what the government said was a recurring lung infection.

In Sunday's statement, Zuma also discussed the government's acknowledgement a day earlier that an ambulance carrying Mandela to the hospital two weeks ago had engine trouble, requiring the former president to be transferred to another ambulance for his journey to the hospital.

"There were seven doctors in the convoy who were in full control of the situation throughout the period. He had expert medical care," Zuma said. "The fully equipped military ICU ambulance had a full complement of specialist medical staff including intensive care specialists and ICU nurses. The doctors also dismissed the media reports that Madiba suffered cardiac arrest. There is no truth at all in that report."

Mandela is seen by many around the world as a symbol of reconciliation, and Zuma appealed to South Africans and the international community to pray for the ailing ex-president, his family and the medical team attending to him.

The ruling party expressed concern about the deterioration in Mandela's health.

"We welcome the work being done by The Presidency to ensure that South Africans and people of the world are kept informed on the state of Madiba's health," the party said. "The African National Congress joins The Presidency in calling upon all of us to keep President Mandela, his family and his medical team in our thoughts and prayers during this trying time."

Prior to Zuma's statement late Sunday, reports from the government, former President Thabo Mbeki and a grandson of Mandela had indicated that the health of Mandela was improving, even though he has been in the hospital for treatment several times in recent months. Mandela last made a public appearance in 2010, and has become increasingly frail in recent years.

On April 29, state television broadcast footage of a visit by Zuma and other leaders of the African National Congress to Mandela's home. Zuma said at the time that Mandela was in good shape, but the footage ? the first public images of Mandela in nearly a year ? showed him silent and unresponsive, even when Zuma tried to hold his hand.

Source: http://news.yahoo.com/south-africa-nelson-mandela-critical-condition-201653072.html

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2 Mo. women charged in antifreeze poisoning deaths

KANSAS CITY, Mo. (AP) ? A Missouri woman and her daughter confessed to fatally poisoning two relatives with antifreeze and attempting to kill a third over a 14-month period, according to court documents.

Diane Staudte, 51, of Springfield, was charged Friday with two counts of first-degree murder, one count of first-degree assault and one count of armed criminal action. Her daughter, Rachel Staudte, 22, was charged with the same counts Saturday.

Both women are jailed without bond. A spokeswoman for the Greene County prosecutor's office didn't immediately return an email Saturday from The Associated Press. It wasn't clear if the women had attorneys.

Diane Staudte initially told law enforcement that her husband, Mark Staudte, 61, hadn't been feeling well and suffered from seizures before his April 2012 death, the probable cause statement said. And she said her son, Shawn Staudte, 26, had been sick with flu-like symptoms before his death in September.

The medical examiner in Greene County at first ruled that the husband died of natural causes and the son as a result of prior medical issues. But an anonymous tip led authorities to re-examine the deaths earlier this month following the hospitalization of Diane Staudte's daughter, 24-year-old Sarah Staudte, the statement said.

A detective wrote that a nurse told him that although Sarah Staudte's condition was potentially fatal, Diane Staudte had visited only a couple times and not stayed long. The nurse described Diane Staudte's actions as "inappropriate," saying she joked and laughed with hospital personnel. The nurse also told the detective that Diane Staudte told her that she planned to go on an upcoming vacation to Florida regardless of her daughter's status.

A doctor told the detective that Sarah Staudte's condition was "very suspicious" and said he suspected the young woman had been poisoned.

Diane Staudte admitted under questioning to poisoning her family by putting antifreeze in their soda and Gatorade over several days, the statement said.

She told the detective that she killed her husband because she "hated him" and her son because he was "worse than a pest." She said she wanted to kill her daughter, Sarah, because the young woman "would not get a job and had student loans that had to be paid," the probable cause statement said.

The Springfield News-Leader, citing the probable cause statement in Rachel Staudte's case, said Diane Staudte originally told police she was the only one involved. But the statement said that when Rachel Staudte was confronted with evidence, she admitted to taking part in the deaths and assault.

During a subsequent interview, Diane Staudte then admitted that she and Rachel Staudte had planned, researched and committed the crimes together, the statement said.

Source: http://news.yahoo.com/2-mo-women-charged-antifreeze-poisoning-deaths-004220618.html

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US Tells Hong Kong to Turn Over Snowden (ABC News)

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Sunday, June 23, 2013

triple a travel: Successful Tele Selling - FreeArticleZines Free Article ...

Tele selling is an significant avenue for sales for most business establishments in the present time eventuality. While most people make use of tele selling, there are just 1 or 2 who?re profitable. In case you wish to be productive too, make sure that you abide by the provided tips.

Smile, when you?re tele selling your goods. While the person on the other end of the phone may not observe your facial expression, he or he?s going to definitely feel it. Smiling not only makes you more confident however additionally gives your voice a pleasing undertone. Moreover, when you smile, you?re bound to feel relaxed and that will also reflect in your voice. So, when you sound confident, pleasant and chilled, the individual you?re calling is certain to be more willing to lend an ear to what you are saying.

Learn to listen to your clients. Most tele executives are more engaged in narrating their part of the tale than listening to what the customer has to say. This disposition may merely frustrate the receiver of your call and so you must make it a point to hear what the other person is saying before continuing with what you ought to say. Do not multitask when on a call as you might not be able to listen to what?s being stated. By lending a patient and alert ear, you will be able to make your discussion more productive.

To make sure that you have an engaging and smooth conversation, include various open ended investigations in the call. This can give a chance to the receiver to speak his/her mind. In reality it?s much better in case the prospective customer is at the speaking end more than you. Purpose being this creates a comfortable atmosphere for the recipient. This may aid you coax the person to go ahead with the purchase.

Come in rhythm to the recipient?s style of talking. In case the person at the other end of the phone speaks softly and carefully, try to take up the same speaking style. As the pace plus the style of speaking reaches a common zone, the chances of successful chat raises manifolds. The recipient develops an affinity with the caller and thereby strikes an engaging chat.

Besides the above mentioned tips, you could also look at recording your calls to increase your success quotient. Recording your calls and listening to them will aid you understand the areas where you could improve. You may wish to say ?Hi? in a distinct tone all together. Or you might realize that your articulation is not very apparent to the other person. Work on your flaws and you will manage to collect success for sure.

So, in case you desire your tele selling to bring the preferred revenue and profits, it makes sense to take on the given tips at the earliest.

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Paula Deen's not alone: 8 celeb apologies

Pop culture

2 hours ago

Paula Deen made three apology videos after admitting to using using racial slurs (and not showing up for a TODAY appearance to discuss it) but her many mea culpas weren't enough to save her job -- Food Network announced Friday her contract won't be renewed.

IMAGE: Charlie Sheen, Kristen Stewart and Kanye West

NBC / Getty Images Contributor

Charlie Sheen, Kristen Stewart and Kanye West all were sorry for something.

Deen's not the only celebrity who's had to publicly admit an error after a less-than-stellar act. Here are eight eating-crow moments.

Kristen Stewart: Sorry for cheating
In 2012, Kristen Stewart had a fling with Rupert Sanders, the married director of her film, "Snow White and the Huntsman." The "Twilight" star apologized not only to her boyfriend Robert Pattinson, but to her fans, saying "I apologize to everyone for making them so angry. It was not my intention." That didn't stop the terribly tacky T-shirts braying, "Kristen Stewart is a Trampire."

Lance Armstrong: I'm sorry, but everybody did it
Cyclist Lance Armstrong had the right venue for a public celebrity apology for his doping -- he went on TV with Oprah Winfrey, the queen of the celebrity confessional. But he wanted to apologize about as much as he wanted someone to pass him in his numerous Tour de France races. "I made my decisions, they are my mistakes, and I am sitting here today to acknowledge that and to say I?m sorry for that," he said. But he also went on to say using banned substances for a cyclist was like having "air in our tires." Cycling fans viewed the whole apology as a lot of hot air.

Tiger Woods: 'I had affairs'
Thanksgiving 2009 wasn't a nice family occasion for golfer Tiger Woods. His well-publicized one-car crash revealed that he was cheating on his wife, the mother of his two young children. "For all that I have done, I am so sorry," Woods would say in his apology months later. "I had affairs, I cheated. What I did was not acceptable, and I am the only person to blame." He piled praise on wife Elin, but there wasn't enough praise in the world for what she'd found out. They divorced that August.

Mel Gibson: Where did those slurs come from?
Actor Mel Gibson bragged that he "owned Malibu" when he was arrested there for DUI in 2006, but he only got worse when he started bellowing anti-Semitic remarks to the Jewish police officer arresting him. "I said horrible things to him," Gibson later admitted. Later at the station, he called a female officer "sugar (expletive)." In his televised apology, Gibson laughed uncomfortably and claimed he didn't know where the slurs came from. The apology didn't convince everyone, but in 2011, Robert Downey Jr. begged his fellow actors to forgive Gibson, saying he'd helped him through his own struggles and deserved compassion.

David Letterman: Funny man gets serious
Talk-show host David Letterman couldn't apologize without a little humor. When a 2009 extortion plot revealed that Letterman had a relationship with his former show assistant, the comic joked that even "the navigation lady (in my car) wasn't speaking to me." Then he got serious, apologizing to his wife and his staff. But the jokes were everpresent. He also said, "This is only phase one of the scandal. Phase two, next week I go on 'Oprah' and sob."

Hugh Grant: What the hell WAS he thinking?
Jay Leno got right to the point when actor Hugh Grant went on "The Tonight Show" after being caught with a prostitute in 1995. "What the hell were you thinking?" Leno asked. Grant ran down the excuses he could have used and then discarded them all, admitting, "I did a bad thing and there you have it." His willingness to face up to his "bad thing" makes his apology one of the best-received in a crowded field of star "I'm sorrys."

Charlie Sheen: I'm sorry, kind of, but not really
Google "Charlie Sheen apology" and you fall down a rabbit hole of options. "Sheen apologizes for party comments," "Sheen apologies for gay slur," "Sheen apologizes to Ashton Kutcher." But one of our favorites was when Sheen apologized to "Two and a Half Men" co-star Jon Cryer, whom he'd called a "turncoat, a traitor and a troll," apparently for not going to bat for Sheen when he was fired from their hit sitcom. Sheen apologized, then took half of it back because he was apparently still mad. "It's a little bit a half apology," he said. "An apol."

Kanye West: Mom wouldn't be happy
Like Hugh Grant, rapper Kanye West took to "The Tonight Show With Jay Leno" to apologize for his infamous 2009 interruption of Taylor Swift at the MTV Video Music Awards. "It was rude, period," he said of his behavior. Then Leno asked him what his late mother Donda would've thought of the incident. West, who was very close to his mom, paused for a long break before admitting she wouldn't have been happy. Mother knows best.

Source: http://www.today.com/entertainment/paula-deens-sorry-shes-not-alone-8-celebrity-apologies-6C10411626

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Supreme Court has range of options on gay marriage

WASHINGTON (AP) ? The waiting is almost over.

Sometime in the next week or so, the Supreme Court will announce the outcomes in cases on California's Proposition 8 ban on same-sex marriage and the federal Defense of Marriage Act.

The federal law, known by the shorthand DOMA, defines marriage as the union of a man and a woman and therefore keeps legally married gay Americans from collecting a range of federal benefits that generally are available to married people.

The justices have a lengthy menu of options from which to choose. They might come out with rulings that are simple, clear and dramatic. Or they might opt for something narrow and legalistic.

The court could strike down dozens of state laws that limit marriage to heterosexual couples, but it also could uphold gay marriage bans or say nothing meaningful about the issue at all.

A look at potential outcomes for the Proposition 8 case and then for the case about DOMA:

___

Q. What if the Supreme Court upholds Proposition 8?

A. This would leave gay Californians without the right to marry in the state and would tell the roughly three dozen states that do not allow same-sex marriages that there is no constitutional problem in limiting marriage to a man and a woman.

Such an outcome probably would trigger a political campaign in California to repeal Proposition 8 through a ballot measure, which opinion polls suggest would succeed, and could give impetus to similar voter or legislative efforts in other states. Proposition 8 itself was adopted by voters in 2008, but there has been a marked shift in Americans' attitudes about same-sex marriage in the past five years.

___

Q. What if the court strikes down Proposition 8?

A. A ruling in favor of the two same-sex couples who sued to invalidate the gay marriage ban could produce one of three possibilities. The broadest would apply across the country, in effect invalidating constitutional provisions or statutes against gay marriage everywhere.

Or a majority of the justices could agree on a middle option that applies only to California as well as Colorado, Hawaii, Illinois, Nevada, New Jersey and Oregon. Those states already treat gay and straight couples the same in almost every respect through civil unions or domestic partnerships. The only difference is that gay couples there are not allowed to marry.

This so-called seven-state solution would say that the Constitution forbids states to withhold marriage from same-sex couples while giving them all the basic rights of married people. But this ruling would not implicate marriage bans in other states and would leave open the question of whether states could deprive gay couples of any rights at all.

The narrowest of these potential outcomes would apply to California only. The justices essentially would adopt the rationale of the federal appeals court that found that California could not take away the right to marry that had been granted by the state Supreme Court in 2008, before Proposition 8 passed.

In addition, if the Supreme Court were to rule that gays and lesbians deserve special protection from discriminatory laws, it is unlikely that any state ban on same-sex marriage could survive long, even if the justices don't issue an especially broad ruling in this case.

___

Q. Are there other potential outcomes?

A. Yes, the court has a technical way out of the case without deciding anything about same-sex marriage. The Proposition 8 challengers argue that the private parties defending the provision ? members of the group that helped put the ban on the ballot ? did not have the right to appeal the trial judge's initial decision striking it down, or that of the federal appeals court.

The justices sometimes attach great importance to this concept, known as "standing". If they find Proposition 8's proponents lack standing, the justices also would find the Supreme Court has no basis on which to decide the case.

The most likely outcome of such a ruling also would throw out the appeals court decision that struck down the ban but would leave in place the trial court ruling in favor of same-sex marriage. At the very least, the two same-sex couples almost certainly would be granted a marriage license, and Gov. Jerry Brown, D-Calif., who opposes Proposition 8, probably would give county clerks the go-ahead to issue marriage licenses to same-sex couples.

___

Q. Are the possibilities for the DOMA case as complicated?

A. No, although there are some technical issues that could get in the way of a significant ruling.

___

Q. What happens if the court upholds Section 3 of DOMA, defining marriage for purposes of federal law as the union of a man and a woman?

A. Upholding DOMA would not affect state laws regarding marriage but would keep in place federal statutes and rules that prevent legally married gay Americans from receiving a range of benefits that are otherwise available to married people. These benefits include breaks on estate taxes, health insurance for spouses of federal workers and Social Security survivor benefits.

___

Q. What if the court strikes down the DOMA provision?

A. A ruling against DOMA would allow legally married gay couples or, in some cases, a surviving spouse in a same-sex marriage, to receive benefits and tax breaks resulting from more than 1,000 federal statutes in which marital status is relevant. For 83-year-old Edith Windsor, a New York widow whose case is before the court, such a ruling would give her a refund of $363,000 in estate taxes that were paid after the death of her spouse, Thea Spyer. The situation could become complicated for people who get married where same-sex unions are legal, but who live or move where they are not.

___

Q. What procedural problems could prevent the court from reaching a decision about DOMA?

A. As in the Proposition 8 case, there are questions about whether the House Republican leadership has standing to bring a court case to defend the law because the Obama administration decided not to.

House Republicans argue that the administration forfeited its right to participate in the case because it changed its position and now argues that the provision is unconstitutional.

If the Supreme Court finds that it does not have the authority to hear the case, Windsor probably would still get her refund because she won in the lower courts, but there would be no definitive decision about the law from the nation's highest court and it would remain on the books. It is possible the court could leave in place appeals court rulings covering seven states with same-sex marriage: Connecticut, Maine, Massachusetts, New Hampshire, New York, Rhode Island and Vermont.

___

Follow Mark Sherman on Twitter: http://twitter.com/shermancourt

Source: http://news.yahoo.com/supreme-court-range-options-gay-marriage-071707199.html

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2013 All-County Girls Track and Field: Ponte Vedra's Nicole Greene ...

When Ponte Vedra?s Nicole Greene started messing around with the high jump during middle school, little did she know the path that would emerge from it led to dominance in the state and a shot at making her name in the national arena. With three years of varsity experience, two state titles and another pair of track seasons still to come, the budding star has shown all the tools necessary for a long, successful career in the sport.

Greene, the St. Johns County St. Augustine Record Girls Track and Field Athlete of the Year, keeps toying with her competition to this day.

?It?s definitely not something I expected to happen; I was quite surprised at first,? Greene said. ?I really love it now. It took me by surprise.?

As a sixth-grader at Episcopal, Greene participated in the more fashionable events ? 100-meter dash, 200 and 4x100 relay. The high jump started as an attempt at filling idle time during track practice late in seventh grade. Then a coach saw her clearing 5 feet with ease without any idea of what she was doing, and after that, sprints became an afterthought.

Her first appearance at the state meets resulted in a second-place finish in Class 2A as an eighth-grader.

After transferring her freshman year to Ponte Vedra for the school?s Academy of Biotechnology and Medical Research (both her parents are doctors and Greene hopes to follow suit), she found immediate success with the Sharks on the track, winning her first Class 3A championship with a height of 5-6.

Though her state win this year came at a height of 5-5, it was on a rainy and windy day the University of North Florida that hurt times and heights across the board.

Greene hit 5-10 consistently this season, putting her eighth nationally in 2013. At the New Balance Nationals Outdoor held on Sunday, she took third.

As her control of the state continues, Greene has shifted her focus to her future. Some colleges have already made their interest known, but are unable to make an honest recruitment until her junior year.

That list includes UCLA, Louisville, Mississippi and Miami. Despite her career potential in track, Greene still looks for a school with a strong medical program ? that?s why Miami would be a nice fit and schools like North Carolina, University of Pennsylvania and Stanford round out her top choices.

But until colleges can make their recruitments in earnest, Greene is focusing on continuing her development.

She added a personal coach last year, Harold Rose, who won a state title as part of Wolfson?s 2005 championship team before later attending Bethune-Cookman on a track scholarship. He?s worked with Bartram Trail in the past, helping their team win its first track state title.

With Greene, what sets her apart in Rose?s eyes ? other than the natural talent ? is her demeanor.

She brings an intelligence and maturity to her practices not common for kids still without a driver?s license.

In his second year as her coach, Rose is more focused on refining technique than wholesale changes.

?Right now she just has to focus on enjoying the competition,? Rose said. ?She?s at a point where she?s still learning (high jump).?

Though the goal couldn?t be any simpler ? raise a bar, jump over it without knocking it over ? making the leap from regionally good to nationally dominant takes much more than physical prowess.

Understanding how the body travels and arches through the air is as important as the leg strength needed to clear the bar. Learning from what distance to start the jump and when to curl your body up and over may be a difference of inches, but for Greene?s purposes those inches often determine success and failure.

One day, she hopes, those inches will be the difference in medal color.

Though it?s still far away, the 2016 and 2020 Olympics are still in the back of Greene?s mind with each training session.

Heights of 5-10 and higher were the minimum to make the Olympic Trials for last year?s London games, a height that she?s been able to hit consistently all year.

By the end of the summer, Rose wants Greene to be clearing the 6-foot mark consistently, something she can already do occasionally during practice. By the end of her junior track season, the goal will be 6-2.

For contrast, 30-year-old Russian Anna Chicherova took gold in the high jump last year with a height of 2.05 meters (just over 6-7). At 16, Greene has already eclipsed the 6-foot mark in practice sessions while still physically maturing into an adult.

What can be measured by a squat rack isn?t the reason for Greene?s success as of yet. Luckily for her, it?s also not what she depends upon.

The strength will come with time and training. It?ll be joined with ever-deepening knowledge of the details in such a surface-simple event.

?Nicole?s a joy to work with; she?s so cerebral,? Rose said. ?At this point, watching her grow is a joy. There?s so much upside to her once she understands the intricacies of the event.?

Rose still believes that adding 1.5 to 2 inches every year is still a realistic short-term goal for Greene, certainly when considering her natural gift for the sport paired with the work ethic and intelligence shown so far.

?Right now, it?s more a matter of when I take off and get in the air,? Greene said. ?It?s the little details that help you get over 6 feet, but after that it gets a little easier.?

Nothing feels out of the question for Greene by the time she finishes her senior year in 2015. She?s surpassed the need to prove herself in the state of Florida.

Improving is now a self-maintaining goal. It always is with any track competition, but the heights possible in Greene?s career are only now beginning to come in view.

?(Greene) had ?it? when I first saw her,? Rose said. ?She enjoys learning the event and being competitive. The Olympics are something that she wants to accomplish, and with her work ethic and ability, I can?t see why that couldn?t happen.?

Source: http://staugustine.com/sports/local-sports/2013-06-20/2013-all-county-girls-track-and-field-ponte-vedras-nicole-greene

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Saturday, June 22, 2013

Modern Combat 4 Meltdown update to include new maps, game modes, and weapons

Modern Combat 4

Gameloft has announced that their excellent first-person shooting game for Android,m Modern Combat 4, will be updated with a bunch of new content. We've got three new maps called Fracture, Extraction, and Backfire, a new grenade launcher pistol, a new sniper rifle, two new multiplayer game modes, two new perks, and a new demolitions specialization (because blowing stuff up is kinda fun). 

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Source: http://feedproxy.google.com/~r/androidcentral/~3/Ze6Q-CZQuuI/story01.htm

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Mindscapes: Transported by seizures to a land of bliss

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Source: http://www.labspaces.net/128745/Mindscapes__Transported_by_seizures_to_a_land_of_bliss

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Ravi K. Perry: Alan Chambers' Apology

Apologies are hard to come by. Just think about the many apologies you deserve from people and groups that you have not received and likely will never get.

In thinking about the significance of the Exodus International apology, I was reminded of James Baldwin's famous statement that "love takes off masks that we fear we cannot live without and know we cannot live within."

Exodus International is a group that, for nearly four decades, had been a leader in "ex-gay" circles and aggressively promoted efforts, programs, and resources devoted to "helping" non-heterosexual Christians become straight.

However, as news outlets reported today, they have since begun the process of shutting down, and, in doing so, they issued an apology -- not to the church but to the LGBT communities this organization vilified in the name of Christ for far too long.

Clearly, the beliefs and projects they once vigorously promoted have caused irreparable damage to many throughout this nation. An apology won't change that.

However, an apology does take courage. And for those of us who do identify as Christian and also happen to not be heterosexual, the Exodus International apology is very moving and marks an important step on the road toward equality, equity, and universal freedom.

His apology suggests that there is an increasing understanding, even in "ex-gay" circles, that no Christian denomination, religiously affiliated organization, or self-identifying member of the faith has a divine right to push their interpretation of their faith on others (particularly those who share the same faith).

His apology moves me as it reminds me of troubles I've had in Christian churches across the country. Prior to joining any congregation, I have always insisted on meeting personally with the church pastor. In committing to detailed, difficult dialogue on divisive issues such as gay rights, I've often been told by many ordained Christian pastors that those denominations that accept non-heterosexuals openly into the body of Christ are "not the real Christians"; according to these pastors, they are "confusing the will of God with the work of the devil" and so on.

This is why the Chambers and Exodus International apology is very important. While it's just one example, the voluntary apology sheds new light and offers new hope that key members and groups of and within the Christian faith -- in all its diversity -- can possibly coexist, without one group or individual suggesting their interpretation of what is the right Christian thing to do is the only way.

Invoking strong themes of contestation, in the open apology to members of the LGBT communities, Alan Chambers, the current leader of Exodus International, tells of a deep, conflicted, personal, and organizational moral journey that resulted in the open apology letter.

In the letter, Chambers says, "[O]ur ministry has been public and therefore any acknowledgement of wrong must also be public."

His apology, he insists, is not only on behalf on Exodus International and himself but on behalf of church.

Strikingly, he writes:

"But if the Church is a body, with many members being connected to the whole, then I believe that what one of us does right we all do right, and what one of us does wrong we all do wrong. We have done wrong, and I stand with many others who now recognize the need to offer apologies and make things right. I believe this apology -- however imperfect -- is what God the Father would have me do.

Admitting to causing bountiful hurt, damage, and trauma -- this is a real apology. LGBT communities should welcome the apology. Despite the many wrongs committed, a public, full admission of those wrongs is so courageous and so rare -- and it is the right thing to do.

Stopping short of supporting homosexual sexual behavior or marriage equality, though, Chambers does cite the need to be a productive citizen in our "pluralistic culture."

While there will continue to be disagreements I and others hold with Chambers regarding some of his beliefs, the fact that he now recognizes that everyone and every Christian has a right to interpret those beliefs as they see fit in this pluralistic nation is worthy of grace.

?

Follow Ravi K. Perry on Twitter: www.twitter.com/raviperry

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Source: http://www.huffingtonpost.com/ravi-k-perry/alan-chambers-apology_b_3473791.html

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Friday, June 21, 2013

Samsung Galaxy Mega 6.3 revisits the FCC with AT&T-native LTE

Samsung Galaxy Mega 6.3 revisits the FCC with AT&T native LTE

Yes, we've seen Samsung's Galaxy Mega 6.3 at the FCC before. With its second visit, however, there's something special. The extra-large phone is back as the SGH-i527, and it's carrying AT&T-native LTE that hints at a probable US carrier deal. There aren't any other visible changes in the filing, although we weren't expecting any. The real question is when this behemoth will ship to the States, assuming it ships at all -- for now, any possible AT&T launch remains shrouded in mystery.

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Source: http://www.engadget.com/2013/06/19/samsung-galaxy-mega-6-3-revisits-the-fcc-with-att-native-lte/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Some parents want their child to redeem their broken dreams

June 19, 2013 ? Some parents desire for their children to fulfill their own unrealized ambitions, just as psychologists have long theorized, according to a new first-of-its-kind study.

Researchers found the more that parents see their child as part of themselves, the more likely they are to want their child to succeed in achieving their own failed dreams.

The results might help explain the actions of so-called "stage moms" or "sports dads" who push their sometimes-unwilling children to become stars of the stage or gridiron, said Brad Bushman, co-author of the study and professor of communication and psychology at The Ohio State University.

"Some parents see their children as extensions of themselves, rather than as separate people with their own hopes and dreams," Bushman said.

"These parents may be most likely to want their children to achieve the dreams that they themselves have not achieved."

The study was led by Eddie Brummelman of Utrecht University in the Netherlands. It appears online today (6/19) in the journal PLOS ONE.

The results, while not surprising, had not previously been the subject of empirical research, Bushman said.

"Right from the beginning of psychology, there have been theories that parents transfer their own broken dreams onto their children," he said. "But it really hasn't been experimentally tested until now."

The study, conducted in the Netherlands, involved 73 parents (89 percent mothers) of a child aged 8 to 15.

Parents first completed a scale designed to measure how much they saw their children as part of themselves -- from completely separate to nearly the same. This scale is commonly used in psychology, and has been found to be very reliable, Bushman said.

The participants were then randomly separated into two groups. In one group, the parents listed two ambitions they had not been able to achieve in their lives, and wrote about why these ambitions were important to them. The other group completed a similar exercise, but focused on an acquaintance's ambitions rather than their own.

Some of the dreams that eluded parents included becoming a professional tennis player, writing a published novel and starting a successful business.

Now that the parents were thinking about unfulfilled ambitions, they were asked several questions that probed their desire to have their child achieve their own lost dreams. For example, they were asked how strongly they agreed with statements like "I hope my child will reach goals that I wasn't able to reach."

Results showed that parents who reflected on their own lost dreams (as compared to those of acquaintances) were more likely to want their children to fulfill them -- but only if they felt strongly that their child was a part of themselves.

Moreover, those who felt strongly that their child was a part of themselves were much more likely to want their children to fulfill their dreams -- but only when they were asked to write about their own unfulfilled ambitions, as opposed to those of acquaintances. (The researchers asked some participants to write about acquaintances to be sure that thinking about one's own unfulfilled ambitions was the key issue and not thinking about unfulfilled ambitions in general.)

Bushman said it was significant that parents who see their children as part of themselves were the ones who transferred their dreams onto their offspring.

"Parents then may bask in the reflected glory of their children, and lose some of the feelings of regret and disappointment that they couldn't achieve these same goals," he said. "They might be living vicariously through their children."

Future research will be needed to determine how this desire of parents for their children to fulfill their dreams may impact the mental health of their offspring, Bushman said.

Other co-authors of the study included Sander Thomaes of Utrecht University and the University of Southampton; and Meike I. Slagt, Geertjan Overbeek and Bram Orobio de Castro of Utrecht University.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/_9It9d6awMo/130619194953.htm

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Samsung unveils the ATIV One 5 Style, a Windows 8 AIO with Galaxy design

Samsung unveils the ATIV One 5 Style, a Windows 8 AIO with Galaxy design

Portables aren't the only ATIV devices Samsung has in store today: Samsung's DJ Lee unveiled the ATIV One 5 Style this afternoon, an all-in-one PC with a slim 4.5mm metal frame and a Galaxy-style white bezel. From what we've seen so far, it's clearly a Windows 8 PC, and it's all screen (of the touch variety). Samsung European PC business director Patrick Povel calls it, "The perfect home entertainment device."

But you've already seen the ATIV One 5, you wanna know what's inside it -- we've just learned a load more about its specs. The ATIV One 5 features an AMD A6 quad-core processor (which also handles graphics duties), and has 4GB of RAM. The 21.5-inch display has a 1920 x 1080 resolution -- we're still not sure what type of screen that is, sadly, but we've asked. The ATIV One 5 Style arrives in the UK "later this year" for an unknown price.

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Source: http://www.engadget.com/2013/06/20/samsung-ativ-one-5-style/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Tuesday, June 18, 2013

U.S. engaging in Syria without a concrete plan, lawmakers fear (cbsnews)

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Cancer Survivor Melissa Etheridge On Angelina Jolie Mastectomy: 'I ...

Angelina Jolie shocked the world when she chose to undergo a double mastectomy after confirming that she carried the BRCA-1 gene, which gave her an 87 percent chance of developing breast cancer. Brad Pitt has raved of her bravery, calling her a ?bada**.?

But now, cancer survivor Melissa Etheridge has come forward to say that she?s anything but.

PHOTOS:? Angelina Jolie Hits The Red Carpet For First Appearance Since Revealing Surgery

?I have to say, I feel a little differently,? the lesbian rocker told gay newspaper The Washington Blade. ?I have that gene mutation too, and [a preventative double mastectomy is] not something I would believe in for myself.?

Melissa, who successfully underwent five rounds of chemo for breast cancer in 2005, said, ?I wouldn?t call [having a preventative mastectomy] a brave choice. I actually think it?s the most fearful choice you can make when confronting anything with cancer.?

PHOTOS: Brad Pitt Shows Off A Different Side In Interview Magazine

What?s more, Melissa believes cancer is simply a matter of mind over matter. ?My belief is that cancer comes from inside you, and so much of it has to do with the environment of your body,? she claims.

?It?s the stress that will turn that gene on or not. Plenty of people have the gene mutation and everything, but it never comes to cancer, so I would say to anybody faced with that, that choice is way down the line on the spectrum of what you can do and to really consider the advancements we?ve made in things like nutrition and stress levels.?

PHOTOS: Stars Rub Elbows Backstage At The Grammys

?I?ve been cancer free for nine years now, ?she says, ?and looking back, I completely understand why I got cancer. There was so much acidity in everything. I really encourage people to go a lot longer and further before coming to that conclusion.?

Angelina, however, is more than happy with her choice, and is already back to ?business as usual,? Brad said on Good Morning America Monday.

Next, she plans to have her ovaries removed within the next two years, as she also faces an elevated risk of ovarian cancer.

Source: http://radaronline.com/exclusives/2013/06/melissa-etheridge-angelina-jolie-mastectomy-not-brave-choice/

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Lowe's offers to buy Orchard Supply for $205M

MOORESVILLE, N.C. (AP) ? Lowe's plans to expand its California presence with an acquisition of Sears spinoff Orchard Supply Hardware Stores for about $205 million in cash.

Orchard Supply filed a voluntary Chapter 11 bankruptcy petition on Monday, so the offer from Lowe's will become the "stalking horse" bid for an auction of Orchard's assets. Such a bid sets the floor for an auction process that lets competitors make better offers.

The California market is key since it has been a strong market for home improvement retailers recently. In its most recent earnings report Lowe's reported net income that rose 3 percent but missed expectations, hurt by a rainy and cool spring. However its larger rival Home Depot Inc., with a bigger presence in California, reported better-than-expected results.

"This transaction is about the convenience deficit that Lowe's currently has relative to Home Depot in key metro markets around the U.S.," said Janney Capital Markets analyst David Strasser. "This acquisition would help immediately in California, and possibly set up a strategy for other key metro markets."

The Lowe's bid must survive the auction and receive bankruptcy court approval. The companies expect the deal to close in about three months.

Orchard Supply filed its bankruptcy petition in the U.S. Bankruptcy Court for the District of Delaware.

Mooresville, N.C.-based Lowe's Cos. Inc. said Monday it will acquire at least 60 of Orchard's 91 stores, and alternative bids must top Lowe's offer by at least $12 million. Lowe's also will assume responsibility for money owed to nearly all of Orchard's suppliers.

Orchard stores are smaller than Lowe's locations, with about 36,000 square feet of selling space compared with 113,000 square feet for Lowe's. The San Jose, Calif., company was spun off from Sears Holdings Corp. in January 2012, and most of its locations are in densely populated California markets.

Lowe's already runs 110 stores in California. It plans to have Orchard operate as a separate, standalone business, retaining the Orchard brand. Lowe's Chairman and CEO Robert A. Niblock said in a statement that Orchard's business has potential but also has been burdened with high debt.

"Strategically, the acquisition will provide us with immediate access to Orchard's high density, prime locations in attractive markets in California, where Lowe's is currently underpenetrated, and will enable us to participate more fully in California's economic recovery," Niblock said.

Lowe's shares rose 21 cents to close at $41.37, closer to the high end of the stock's 52-week range between $24.76 and $43.84. The stock has climbed 16 percent so far in 2013.

Source: http://news.yahoo.com/lowes-offers-buy-orchard-supply-205m-104404778.html

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Monday, June 17, 2013

Rask too tough for Chicago in Boston's 2-1 OT win

Boston Bruins goalie Tuukka Rask (40) seals off the goal against the Chicago Blackhawks in the second period during Game 2 of the NHL hockey Stanley Cup Finals, Saturday, June 15, 2013, in Chicago. (AP Photo/Nam Y. Huh)

Boston Bruins goalie Tuukka Rask (40) seals off the goal against the Chicago Blackhawks in the second period during Game 2 of the NHL hockey Stanley Cup Finals, Saturday, June 15, 2013, in Chicago. (AP Photo/Nam Y. Huh)

Chicago Blackhawks center Jonathan Toews (19) shoots the puck wide against Boston Bruins goalie Tuukka Rask (40) as Boston Bruins defenseman Andrew Ference (21) defends in the third period during Game 2 of the NHL hockey Stanley Cup Finals, Saturday, June 15, 2013, in Chicago. (AP Photo/Charles Rex Arbogast)

Boston Bruins goalie Tuukka Rask (40) reacts as he watches play down the ice against the Chicago Blackhawks in the third period during Game 2 of the NHL hockey Stanley Cup Finals, Saturday, June 15, 2013, in Chicago. (AP Photo/Nam Y. Huh)

Boston Bruins goalie Tuukka Rask (40) watches the rebound after blocking a shot against the Chicago Blackhawks in the first period during Game 2 of the NHL hockey Stanley Cup Finals, Saturday, June 15, 2013, in Chicago. (AP Photo/Charles Rex Arbogast)

(AP) ? A lesser goalie would have been flustered by the Chicago Blackhawks hot start.

Not Tuukka Rask.

After giving up a goal and withstanding another 18 shots in the first period Saturday night, the Boston Bruins goalie may as well have hung a "Not Open" sign on his net. While he stymied the Blackhawks, his teammates regrouped and found enough offense for a 2-1 overtime victory that sent the Stanley Cup finals to Boston tied at one game apiece.

"We definitely were in survival mode there for a bit," Rask said. "It looked like they had more guys out there than we did. They were bouncing on every single puck in front of net, had a lot of chances. We definitely played pretty bad. But it was good we were only down by one, and we regrouped after that."

Rask finished with 33 saves, including stopping Game 1 winner Andrew Shaw cold in OT.

Game 3 is Monday night in Boston.

"We had the perfect start to the game, then we stopped doing what made us successful," Blackhawks coach Joel Quenneville said.

Well, Rask had a lot to do with that.

"He wasn't lucky, he's a good goalie," Chicago's Patrick Sharp said. "He doesn't do anything different. He stops the puck when he sees it."

Boston had the edge in goaltending coming into the series ? and not simply because Chicago is seemingly ready to replace Corey Crawford at the drop of a puck.

Rask was impressive enough last season that he made Stanley Cup winner Tim Thomas expendable, and the 26-year-old from Finland has taken his game to another level this postseason. He came into the series with the highest save percentage (.943) of the playoffs, and limited the high-octane Pittsburgh Penguins to a measly two goals in a four-game sweep by the Bruins in the Eastern Conference finals.

The Blackhawks made Rask look mortal in Game 1, tagging him for four goals ? more than he'd given up in Boston's previous five postseason games combined.

It wouldn't happen a second time.

Chicago came out flying Saturday night, peppering Rask with rapid-fire shots, trying to sneak up on him from behind and playing hot potato with the puck in front of the net in hopes of catching him off-guard and slipping one past. Boston coach Claude Julien called the effort "totally lopsided."

"The first period, we just weren't there. We were on our heels," Julien said. "They had total control of that period. Tuukka kept us in there."

Rask needed his head on a swivel to keep track of the traffic, and even that wasn't always enough.

At about 11 minutes into the first period, the Blackhawks blitzed Rask with a series of shots, two from Patrick Kane and one from Michal Handzus. Rask handled all of them, but the puck squirted out to the right side where Sharp was waiting.

With Rask still preoccupied with the scrum on the opposite side of the net, Sharp poked a goal past him, putting Chicago up 1-0.

"Every goal you let in you have a chance to save. I'm not going to blame myself for that," Rask said. "I think there were three or four saves before that goal. I couldn't find that puck until the last second. But you know, they had 19 shots and one goes by you. It happens sometimes."

It happened again shortly after when Marian Hossa appeared to score. But officials waved off the goal, saying play had been stopped.

When the first period finally ended, the Blackhawks had a 19-4 shot advantage.

"Not much needed to be said after that first period," Chris Kelly said. "I think Tuukka pointed out that was a pretty terrible period by our team. If it wasn't for Tuukka, it would have been a lot worse. To a guy in there, I think we all knew we had to go out and play better."

Boston's defense tightened up, and Rask easily handled the few remaining chances the Blackhawks had. Chicago had only 15 shots in the last two periods and overtime.

"That first period was extremely hard for (Rask)," Julien said. "But, thankfully, our guys rewarded him with that effort by being a lot better in front of him for the rest of the game."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-16-HKN-Stanley-Cup-Key/id-1b38e117fde44573ac6420485621734f

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Ryan Hunter-Reay wins at Milwaukee again

WEST ALLIS, Wis. (AP) ? Ryan Hunter-Reay continued Andretti Autosport's domination at the Milwaukee Mile, winning the IndyCar event Saturday for the second year in a row.

Hunter-Reay became the first driver to win back-to-back races at the Mile since Tony Kanaan in 2006 and 2007 when he was driving for ? you guessed it, Andretti.

Andretti drivers have won five of the last nine races at the mile oval and nearly had a perfect day Saturday in a race that is promoted by Michael Andretti's marketing company. Hunter-Reay got the win, E.J. Viso finished fourth and James Hinchcliffe was fifth.

The only blemish was pole-sitter Marco Andretti, who led the first 62 laps before his day fell apart with a mechanical issue.

For Hunter-Reay, it was the second win of the season for the defending IndyCar Series champion. This one came at the site of the track he used to jumpstart last year's title run ? Hunter-Reay reeled off three consecutive wins starting with Milwaukee last season to climb into the championship race.

This year, though, he got to celebrate an early Father's Day gift with son, Ryden.

"Those last few laps I was thinking, 'Man, I've got to do this for him,' " Hunter-Reay said. "It's so special, he's 6-months-old, getting to have my little guy here in Victory Lane is the best Father's Day gift."

IndyCar Series points leader Helio Castroneves was second and followed by Penske Racing teammate Will Power as Chevrolet swept the podium. It was the first podium finish this season for Power, who hasn't won a race since Brazil last year.

He made a bold attempt to pass Castroneves for second in the closing laps before cautiously backing off a touch. Power said after the race he had to consider the big picture and that his teammate is the current points leader while racing for position.

Scott Dixon was sixth in the highest finishing Honda and was followed by Takuma Sato, who dominated the early section of the race but was shuffled out of contention because of pit cycles. Still, it was the best finish for an A.J. Foyt Racing entry at Milwaukee since Foyt himself was fifth in 1988.

Dario Franchitti, Justin Wilson and Kanaan rounded out the top 10.

Marco Andretti wound up 20th and was passed by teammate Hunter-Reay for second in the IndyCar standings.

Source: http://news.yahoo.com/ryan-hunter-reay-wins-milwaukee-again-224100378.html

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Afghans poised to take security lead from US, NATO

In this Thursday, June 13, 2013 photo, Afghan National Army soldiers march in Sangin district of Kandahar province southern Afghanistan. One of the most significant turning points in one of America's longest and costliest wars is imminent: Afghanistan's fledgling security forces are taking the lead for security nationwide, bringing the moment of truth on the question of whether they are ready to fight an insurgency that remains resilient after nearly 12 years of conflict. That question is especially pressing here in this border region where insurgents regularly ambush government forces and control parts of the countryside. (AP Photo/Allauddin Khan)

In this Thursday, June 13, 2013 photo, Afghan National Army soldiers march in Sangin district of Kandahar province southern Afghanistan. One of the most significant turning points in one of America's longest and costliest wars is imminent: Afghanistan's fledgling security forces are taking the lead for security nationwide, bringing the moment of truth on the question of whether they are ready to fight an insurgency that remains resilient after nearly 12 years of conflict. That question is especially pressing here in this border region where insurgents regularly ambush government forces and control parts of the countryside. (AP Photo/Allauddin Khan)

In this Thursday, June 13, 2013 photo, An Afghan National Army soldier aims his weapon, in Sangin district of Kandahar province southern Afghanistan. One of the most significant turning points in one of America's longest and costliest wars is imminent: Afghanistan's fledgling security forces are taking the lead for security nationwide, bringing the moment of truth on the question of whether they are ready to fight an insurgency that remains resilient after nearly 12 years of conflict. That question is especially pressing here in this border region where insurgents regularly ambush government forces and control parts of the countryside. (AP Photo/Allauddin Khan)

In this Thursday, June 13, 2013 photo, Afghan National Army soldiers stand in position, in the Sangin district of Kandahar province southern Afghanistan. One of the most significant turning points in one of America's longest and costliest wars is imminent: Afghanistan's fledgling security forces are taking the lead for security nationwide, bringing the moment of truth on the question of whether they are ready to fight an insurgency that remains resilient after nearly 12 years of conflict. That question is especially pressing here in this border region where insurgents regularly ambush government forces and control parts of the countryside. (AP Photo/Allauddin Khan)

In this Wednesday, June 12, 2013 photo, Al Hajj Malak Nazir, director of the provincial council, speaks during an interview in Jalalabad east of Kabul, Afghanistan. Nazir is convinced the Taliban will keep fighting after Afghanistan's army and police shortly take control for security around the country from the U.S.-led NATO coalition, but he is equally confident they will not get very far. (AP Photo/Rahmat Gul)

In this Saturday, June 15, 2013 photo, Afghan National Army soldiers attend their graduation ceremony in Kabul, Afghanistan. One of the most significant turning points in one of America's longest and costliest wars is imminent: Afghanistan's fledgling security forces are taking the lead for security nationwide, bringing the moment of truth on the question of whether they are ready to fight an insurgency that remains resilient after nearly 12 years of conflict. That question is especially pressing here in this border region where insurgents regularly ambush government forces and control parts of the countryside. (AP Photo/Rahmat Gul)

(AP) ? One of the most significant turning points in one of America's longest and costliest wars is imminent: Afghanistan's fledgling security forces are taking the lead for security nationwide, bringing the moment of truth on the question of whether they are ready to fight an insurgency that remains resilient after nearly 12 years of conflict.

Nowhere is that question more pressing than in this city near the Pakistani border, which is the capital of Nangarhar province. In the province, which has a predominantly Pashtun population, the ethnic group that makes up the Taliban, insurgents regularly ambush government forces, blow up the offices of humanitarian organizations, and control parts of a countryside that has seen a spike in opium poppy cultivation.

Nangarhar is considered so dangerous that foreign military forces still handle security in more than half of its 22 districts.

That will change, after Afghan President Hamid Karzai declares ? in an announcement expected soon ? that Afghan forces are taking over security around the country and U.S. and other foreign forces will move entirely into a supporting, backseat role. At that point, the remaining districts in Nangarhar, along with other hotspots still in the hands of the U.S.-led International Security Assistance Force, will become the Afghan troops' full responsibility.

Residents of Jalalabad, a bustling trading hub and agricultural center on the junction of two rivers, worry about whether the Afghan forces can keep them safe from an insurgency that they say is equipped and trained in neighboring Pakistan. They also fear that the Afghan forces still don't have enough heavy weapons or firepower.

"Our main concern is that for more than 10 years the international community managed to do nothing and that they are now trying to make us strong. It's too little too late," said Lal Mohammad Durrani, a member of the Nangarhar provincial council. "We need more weapons."

NATO training since 2009 has dramatically ramped up the Afghan National Security Forces, bringing it up from 40,000 men and women six years ago to about 352, 000 today. Once the transition is announced, coalition troops will move entirely into a supporting role ? training and mentoring, and in emergency situations providing the Afghans backup in combat, mainly in the form of airstrikes and medevac.

That is to pave the way for international forces ? currently numbering about 100,000 troops, including 66,000 Americans ? to leave. By the end of the year, the NATO force will be halved. At the end of 2014, all combat troops will have left and will replaced, if approved by the Afghan government, by a much smaller force that will only train and advise. President Barack Obama has not yet said how many soldiers he will leave in Afghanistan along with NATO forces, but it is thought that it would be about 9,000 U.S. troops and about 6,000 from its allies.

In a series of wide-ranging interviews with Afghan and western military officials, experts and analysts, opinions are mixed as to the state of readiness of the Afghan forces ? although nearly all agree they are far better now than they were when the NATO training mission began.

British Lt. Gen. Nick Carter, the deputy commander of coalition forces, said the transition to take the lead in security "represents a significant achievement for the Afghan security forces." But, he added, "That said we will require and need to deliver for the Afghans some fairly significant support for a while to come."

Already, Afghans now carry out 90 percent of military operations around the country. They are in the lead in security in 312 districts nationwide, where 80 percent of Afghanistan's population of nearly 30 million lives ? and only 91 districts remain for them to take over ? including 12 in Nangarhar.

The transition comes at a time when violence is at levels matching the worst in 12 years, fueling some Afghans' concerns the forces aren't ready.

"We thought this summer would not be easy for the Afghan security forces, but it was not expected to be like this. We have roadside bombs, we have suicide attacks, organized attacks," said Jawed Kohistani, an Afghan political and military analyst. "It is a mistake to transition this quickly."

Jalalabad's relatively peaceful tree-lined streets are crowded with checkpoints, manned by often edgy Afghan army and police worried about car bombs. Insurgents use the province's mountain passes and valleys to sneak in from neighboring Pakistan, where they retain safe havens in that country's lawless Pashtun-dominated tribal belt. Jalalabad is also just a 3-hour drive through craggy passes and gorges to Kabul, which has seen a spate of spectacular suicide attacks in recent weeks.

Al Hajj Malak Nazir ? the local head of the Afghan High Peace Council, a body created in an attempt to reach out to the Taliban ? said that even though he considers Afghan forces to be under-equipped, he believes they will eventually prevail over the insurgency.

"The Taliban can't take all of Afghanistan. After transition they could take a district, but they won't be able to keep it," he said. That. He added, is why he has been trying to convince the Taliban to enter negotiations.

"This is a very good opportunity for the Taliban to say they will stop fighting. But they won't," he said. "The Americans are now saying they are leaving, but the Taliban never say they are leaving."

Few believe the Taliban will keep promises they have made in the past to stop fighting when foreign military forces are gone. They have not stopped in any province where Afghan forces have taken the lead.

They have also rebuffed numerous attempts to start peace talks in the past year and have instead intensified a campaign that mostly targets urban centers and government installations.

There is overall agreement, however, they don't have much support outside their traditional areas and can't win militarily against the Afghan forces.

"I think, if the Taliban tried to come back, it would have to come back in a very different way. It would have to come back and participate politically," Lt. Gen. Carter said. "It is my sense that civil society, which is the future of this country, absolutely would not put up with sorts of standards that were here 15 years ago. And, therefore, my sense is that ultimately it is the politics that will determine this, and not the violence that determines this."

On battlefields around the country, Afghan forces plan and carry out operations on their own, with little help from coalition forces. They are often effective, but still need work on logistics and effectively using the weapons they have.

Casualty figures are indicative of the fight. More than 330 Afghan army soldiers have died so far this year, according to a tally by the Associated Press.

Last year, more than 1,200 Afghan soldiers died, compared to more than 550 in 2011, according to data compiled by the Washington-based Brookings Institution. By comparison, coalition casualties have declined as they take forces off the battlefield ? 81 so far this year, 394 in 2012 and 543 in 2011.

About 1,481 militants were reported to have been killed by coalition and Afghan forces so far this year, compared with close to 3,000 militants for all of last year. The NATO command does not issue reports on the number of insurgents its troops have killed, and Afghan military figures, from which the AP compiles its data, cannot be independently verified.

"There is no doubt about the ability of the Afghan national army and police. The nation should trust them, and they do," said the Afghan Army Chief of Staff Gen. Sher Mohammad Karimi.

The veteran commander rattled off a series of recent victories over insurgents, including kicking them out of parts of eastern Nuristan that they had controlled for about two years.

"There wasn't a single bit of support from the international community. Only the Afghan national army and national police were able to do that and they did it," he said.

But he grudgingly agreed Afghan troops still need help. That includes the use of coalition air power ? including medical evacuations ? help with locating roadside bombs and further developing the armed forces. They also need to bring down an attrition rate of 3 to 4 percent a month, which means NATO now has to help train 50,000 new recruits a year.

The U.S. has said that Afghanistan will get the weapons it requires to fight an insurgency, including a large fleet of MI-17 transport helicopters, cargo planes and ground support airplanes. The heaviest weapon the Afghan army will have is a howitzer.

"The force is designed according to the threat, and the threat here is an insurgency. The design of the ANSF is appropriate to counter that threat," said German Gen. Hans-Lothar Domrose, the commander of the NATO force that oversees ISAF.

The Afghans, on the other hand, want battle tanks and modern fighter jets ? which they are unlikely to get given their cost and the training required to use them.

The war has already proven very costly

Special Inspector General for Afghan Reconstruction John Sopko last April estimated that the ANSF has so far cost the American taxpayer $54 billion. The overall cost of the war is more difficult to estimate, but for America alone the Center for Strategic and International Studies put the price at about $650 billion through the end of 2013.

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Follow Patrick Quinn on Twitter at: http://www.twitter.com/PatrickAQuinn

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-06-16-Afghan-No%20Turning%20Back/id-8f180d7b15ad42c1a60d325eb6116388

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