Samsung's S Launcher puts the Start menu back in Windows 8

You know those fresh new Series 7 all-in-ones Samsung outed in the wee hours of this morning? Well, it turns out that while those desktops will be running Windows 8, Mashable discovered that they've got a little something extra added to Microsoft's stock OS: a Start Menu. Called the S Launcher, it's a widget that replaces that tried and true Start button the folks in Redmond saw fit to eliminate in Win8. As you might expect, it grants access to settings, files and programs in one convenient window, and making additions to the widget is a drag-and-drop affair. So, all you folks having fits about the Start button's disappearance, fear not, Samsung's got the software to soothe your troubled mind.

Filed under: Software

Samsung's S Launcher puts the Start menu back in Windows 8 originally appeared on Engadget on Tue, 28 Aug 2012 12:33:00 EDT. Please see our terms for use of feeds.

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Mayo study: Exercise can help cancer patients, but few oncologists suggest it

Public release date: 28-Aug-2012
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Contact: Bryan Anderson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

ROCHESTER, Minn. -- Numerous studies have shown the powerful effect that exercise can have on cancer care and recovery. For patients who have gone through breast or colon cancer treatment, regular exercise has been found to reduce recurrence of the disease by up to 50 percent. But many cancer patients are reluctant to exercise, and few discuss it with their oncologists, according to a Mayo Clinic study published in the Journal of Pain and Symptom Management.

"As doctors, we often tell patients that exercise is important, but to this point, nobody had studied what patients know about exercise, how they feel about it and what tends to get in the way," says lead author Andrea Cheville, M.D., of Mayo Clinic's Department of Physical Medicine and Rehabilitation.

The study is part of a series of investigations looking at exercise habits among cancer patients. Researchers found that patients who exercised regularly before their diagnosis were more likely to exercise than those who had not. Many patients considered daily activities, such as gardening, sufficient exercise.

"There was a real sense of 'What I do every day, that's my exercise,'" says Dr. Cheville, noting that most patients didn't realize daily activities tend to require minimal effort. "Most were not aware that inactivity can contribute to weakening of the body and greater vulnerability to problems, including symptoms of cancer."

In addition, researchers found that patients took exercise advice most seriously when it came directly from their oncologists, but none of those studied had discussed it with them.

"Generally, patients are not being given concrete advice about exercise to help them maintain functionality and to improve their outcomes," Dr. Cheville says.

Exercise can improve patients' mobility, enable them to enjoy activities and keep them from becoming isolated in their homes. It can contribute to overall feelings of strength and physical safety, ease cancer-related fatigue and improve sleep. The researchers plan to investigate how to make the message about exercise meaningful to patients to optimize symptom relief and enhance recovery.

###

The study was funded by a grant from the Fraternal Order of Eagles. Other authors include Ann Marie Dose, Ph.D.; Jeffrey Basford, M.D.; Ph.D., and Lori Rhudy, Ph.D.; all of Mayo Clinic.

About Mayo Clinic

Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and www.mayoclinic.org/news.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 28-Aug-2012
[ | E-mail | Share ]

Contact: Bryan Anderson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

ROCHESTER, Minn. -- Numerous studies have shown the powerful effect that exercise can have on cancer care and recovery. For patients who have gone through breast or colon cancer treatment, regular exercise has been found to reduce recurrence of the disease by up to 50 percent. But many cancer patients are reluctant to exercise, and few discuss it with their oncologists, according to a Mayo Clinic study published in the Journal of Pain and Symptom Management.

"As doctors, we often tell patients that exercise is important, but to this point, nobody had studied what patients know about exercise, how they feel about it and what tends to get in the way," says lead author Andrea Cheville, M.D., of Mayo Clinic's Department of Physical Medicine and Rehabilitation.

The study is part of a series of investigations looking at exercise habits among cancer patients. Researchers found that patients who exercised regularly before their diagnosis were more likely to exercise than those who had not. Many patients considered daily activities, such as gardening, sufficient exercise.

"There was a real sense of 'What I do every day, that's my exercise,'" says Dr. Cheville, noting that most patients didn't realize daily activities tend to require minimal effort. "Most were not aware that inactivity can contribute to weakening of the body and greater vulnerability to problems, including symptoms of cancer."

In addition, researchers found that patients took exercise advice most seriously when it came directly from their oncologists, but none of those studied had discussed it with them.

"Generally, patients are not being given concrete advice about exercise to help them maintain functionality and to improve their outcomes," Dr. Cheville says.

Exercise can improve patients' mobility, enable them to enjoy activities and keep them from becoming isolated in their homes. It can contribute to overall feelings of strength and physical safety, ease cancer-related fatigue and improve sleep. The researchers plan to investigate how to make the message about exercise meaningful to patients to optimize symptom relief and enhance recovery.

###

The study was funded by a grant from the Fraternal Order of Eagles. Other authors include Ann Marie Dose, Ph.D.; Jeffrey Basford, M.D.; Ph.D., and Lori Rhudy, Ph.D.; all of Mayo Clinic.

About Mayo Clinic

Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and www.mayoclinic.org/news.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-08/mc-mse082812.php

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Motorola Droid RAZR M 4G LTE Specifications Leaked

NEW YORK (Reuters) - Some two dozen topless women protested in a New York City park on a hot, sweaty Sunday as part of what they called "National Go-Topless Day" to draw attention to inequality in topless rights between men and women. There were topless men in the park, too, but nobody paid them much attention, a disparity, organizers said, that demonstrated the need for the event. The topless women drew crowds of onlookers who took pictures and video with their cell phones. ...

Source: http://news.yahoo.com/motorola-droid-razr-m-4g-lte-specifications-leaked-080627597.html

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Video: Matthews: ?There ought to be a conscience? in politics

Trash Talk: Penn State opens new chapter

Trash Talk: For Penn State, this is the first game of the Bill O'Brien era. He not only has to get a big-time football team to play its first game at home, but he knows the world will be watching to see how the Nittany Lions respond in the post-Paterno era.

Source: http://www.msnbc.msn.com/id/3036697/vp/48806581#48806581

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Japan takes LLWS title, beats Tennessee 12-2

Tokyo's Noriatsu Osaka, right, celebrates with Satoru Aoyama, left, after hitting a walk-off, two-run home run against Goodlettsville, Tenn., in the fifth inning of the Little League World Series championship baseball game in South Williamsport, Pa., Sunday, Aug. 26, 2012. Tokyo won 12-2 in five innings. (AP Photo/Gene J. Puskar)

Tokyo's Noriatsu Osaka, right, celebrates with Satoru Aoyama, left, after hitting a walk-off, two-run home run against Goodlettsville, Tenn., in the fifth inning of the Little League World Series championship baseball game in South Williamsport, Pa., Sunday, Aug. 26, 2012. Tokyo won 12-2 in five innings. (AP Photo/Gene J. Puskar)

Tokyo, Japan's Noriatsu Osaka (10) rounds the bases past Goodlettsville, Tenn., second baseman Lorenzo Butler (8) after hitting a walk-off, two-run home run in the fifth inning of the Little League World Series championship baseball game in South Williamsport, Pa., Sunday, Aug. 26, 2012. Tokyo won 12-2 in five innings. (AP Photo/Gene J. Puskar)

Tokyo, Japan's Noriatsu Osaka celebrates as he rounds the bases after hitting a two-run home run in the fifth inning of the Little League World Series championship baseball game against Goodlettsville, Tenn., Sunday, Aug. 26, 2012, in South Williamsport, Pa. Japan won 12-2 in five innings. (AP Photo/Matt Slocum)

Tokyo's Noriatsu Osaka, second from right, celebrates with teammates after hitting a walk-off, two-run home run against Goodlettsville, Tenn., in the fifth inning of the Little League World Series championship baseball game in South Williamsport, Pa., Sunday, Aug. 26, 2012. Tokyo won 12-2 in five innings. (AP Photo/Gene J. Puskar)

Tokyo, Japan's Noriatsu Osaka celebrates after his two-run home run ended the Little League World Series championship baseball game against Goodlettsville, Tenn., Sunday, Aug. 26, 2012, in South Williamsport, Pa. Japan won 12-2 in five innings. (AP Photo/Matt Slocum)

SOUTH WILLIAMSPORT, Pa. (AP) ? Fast friends in the Little League dorms, the boys from Japan and Tennessee played one last game Sunday to decide which team would be crowned World Series champions.

Noriatsu Osaka's big bat helped send the team from Tokyo home with the title banner.

Osaka's third home run of the game put an exclamation point on Japan's 12-2 victory over Tennessee in five innings in the Little League World Series championship game Sunday.

The 12-year-old Osaka added a triple for good measure in his 4-for-4 afternoon. In a symbolic gesture, Japan's players jogged the traditional postgame victory lap carrying the flags for both their home country and the United States.

"We had such a great time in Pennsylvania and we really played a good game today. It was kind of a, 'Thanks,'" Osaka said through an interpreter.

Starter Kotaro Kiyomiya struck out eight in four innings and added an RBI single for Japan. The game ended in the fifth after Osaka's third homer made it a 10-run game.

"We thought we played the best in the tournament so far, especially to win by the 10-run rule in the finals," said 12-year-old Rintaro Hirano, who homered in the fourth to make it 10-1.

A day after pounding out a 24-16 win over California in the U.S. title game, the Goodlettsville, Tenn., sluggers could only muster two hits ? solo homers by Brock Myers and Lorenzo Butler.

It was a bittersweet final for two teams that grew close during their two weeks in South Williamsport. They exchanged customary postgame handshakes at the plate before Japan received the World Series championship banner and took their warning-track run.

"Tennessee was our best friends in the U.S. division," Kiyomiya said.

Japan's jog finally stopped in front of the team's giddy cheering section as proud family members and friends stood shoulder-to-shoulder to take pictures through the infield fence.

There were so many highlights, including five home runs off Tennessee pitching.

That was more than enough offense for 13-year-old ace Kiyomiya, who had a fastball clocked in the high-70s. The right-hander with the hitch in mid-delivery pitched like a big league ace in allowing just one hit.

Regardless, this is still a banner year for Goodlettsville after its exhausting victory Saturday over Petaluma, Calif., for the U.S. championship. That game set a record for most combined runs in the World Series.

The thrilling victory kept the Tennessee players and their families up late into the night.

"(The parents) must have partied harder than the kids did," manager Joey Hale said. "I knew we'd be flat today."

Tennessee lost a 10-run lead in the bottom of the sixth of that game before scoring nine times the next inning to finally put away Petaluma in a Little League classic. Even more impressively, Butler had three homers and a record nine RBIs ? a feat so unique the 12-year-old's name became a trending topic on Twitter.

Butler went deep again off reliever Osaka in the fifth ? Butler's fourth homer in two days ? to cut the lead to 10-2 and give Goodlettsvile some hope. Tennessee's mini-mashers have proven they can break out any time at the plate.

"It feels really good and it was really great," Butler said simply about his hitting exploits. He said his three homers Saturday were the longest he had hit all season.

Its pitching depth sapped, Tennessee turned to right-hander Justin Smith to start against Japan ? the first time the 12-year-old had pitched in the World Series or in Southeast regional tournament.

"Everybody knew our pitching was depleted and we were bound for a letdown," Hale said. "I'm not saying we were going to beat Japan. I think they were the best team here at everything by far, pitching, hitting. But I think last night is how we want to be remembered."

Leadoff hitter Osaka, 12, didn't waste any time with a first-pitch triple to the right-field corner in the first. Kiyomiya delivered his RBI single two batters later to get the scoring started.

Osaka then homered in the second to left-center, just in front of the "Little League" sign above the fence, before leading off the fourth with his second homer, this time to center, for a 6-1 lead.

The Kitasuna league all-star team from Tokyo won Japan's eighth Little League title and second in three seasons.

While his players danced around in delight after the game, skipper Yoichi Kubo teared up. He kept his composure after managing a team that won the World Series in 2001, "but I was crying this time when we won this game as world champion," he said.

Smith pitched admirably in a tough spot, allowing five runs and seven hits over three innings while striking out three. His team was trying to make history as the first squad from Tennessee to win youth baseball's biggest prize.

Goodlettsville also was the first Tennessee team to advance to South Williamsport since Morristown in 1987. The suburban Nashville crew counts among its fans Rays ace David Price, who is from Murfreesboro.

They might be done with baseball for now, but the celebration is just beginning back home. On Tennessee's social calendar is a visit to the Vanderbilt season opener Thursday night against South Carolina.

"When we get home, it's going to be a carnival," Hale said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-08-27-BBY-Little-League/id-4adcce3824cf4d4c8e9de214182f1af9

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Computer Experts Are Necessary For Any Business | PinoyGwaps

Sorry, Readability was unable to parse this page for content.

Source: http://pinoygwaps.blogspot.com/2012/08/computer-experts-are-necessary-for-any.html

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PST: Man U's win vs. Fulham standard stuff

Man of the Match: Leaving the match after 68 minutes gave this teammates a chance to catch up to Shinji Kagawa. It didn?t happen. After Kagawa left, United lost their nous in the final third, having sacrificed the man who?d been their main creative force. Kagawa was even rewarded for his work in the 35th minute when a spilt Tom Cleverley shot left the former Borussia Dortmund star with a tap in for his first United goal. The Red Devils? best player for the second match in a row, Kagawa may be forcing a subtle but important shift in how United?s organized, a shift emphasized by their assumed leading man starting on the bench.

NBC Sports: Man United beats Fulham 3-2 in Premier League

Packaged for takeaway:

• That?s right: Wayne Rooney was out at the start of this one, though he did come on in the 68th minute (for Kagawa). Coming off a terrible performance Monday night, Rooney?s benching has already been interpreted as him losing favor with United. That?s far too hasty. At worst, this as a message ? a warning shot, of sorts. There?s no reason to believe Ferguson?s doing more than instituting a policy that will keep his stars fresh.
• Robin van Persie also came into the team, a move that paid off early. After poor set piece defending had allowed Damien Duff to give Fulham a 1-0 lead, van Persie half-volleyed a Patrice Evra cross into the right side of Mark Schwarzer?s goal from 14 yards out. The play was defended decently by Brede Hangeland, who was only a half-step away from running onto the cross himself, but an athletic play by van Persie got the shot away with his first touch, leaving Fulham little chance to prevent the equalizer.
• The goal started a United onslaught, the type of attacking pressure most expect to see all season from the Red Devils. Constant runs behind the line kept turning a Fulham defense that lacked the speed to come pressure United (and expose space at the back). The packed in defense was a partial factor in Kagawa and Rafael da Silva?s goals (35? and 41?).
• Fulham got a fortunate own goal from Nemanja Vidic in the second, one that made the final score closer than the actual play. The goal will spark more unfair criticism of David de Gea, though. Vidic bumped Mladen Petric into de Gea in the 65th minute, with Matthew Briggs? cross left to deflect off the defender?s heel and into goal. The immediate reaction from the commentators?recycled?last year?s trope: David de Gea is a problem. On this play, though, the problem was a collision to which any goalkeeper is susceptible.
• The end result was a good United performance against an underrated Fulham team, even if that team played more conservatively than they probably should. Martin Jol?s XI played with two holding midfielders in a 4-4-2, leaving tons of space for Kagawa, Tom Cleverley, and Anderson to control the game. For much of it, United had near 70 percent (Opta) possession, thanks in part to Ashley Young and Antonio Valencia cutting in, augmenting the midfield advantage while da Silva and Evra kept Fulham?s wingers wide.
• Cleverley, playing without Paul Scholes, was much better than Monday. The theory then was Scholes and Cleverley were redundant. Without his teammates deferring to Scholes? experience, Cleverley was able to have an impact in proportion to his talents.
• The bright spot for Fulham was Moussa Dembele, playing along side Mohamadou Diarra in midfield. After a quiet first half where he was marginalized by United?s possession, Dembele was the second half?s best player.
• Did Fulham miss Clint Dempsey? They still scored twice, but they weren?t exactly manufactured goals. The first came from a set piece where Diarra probably should have been called for a foul (throwing an NBA-style pick on Young), while the second was manifest randomness. Though Petric played well, he?s not the type of player you roll a ball to and say ?make something happen.? Neither is Bryan Ruiz, though Demebele seems relatively close, provided some targets. Dempsey was that player for Fulham, the type of player you typically call on when chasing a goal late.
• Late in the match, Rooney had to be stretched off after Hugo Rodallega, following through on a shot from 26 yards, stepped on Rooney?s right thigh. A gash opened up, creating a scene?reminiscent?of Nani?s sliced open shin at the boot of Jamie Carragher two years ago. Rooney was wrapped on the field, carried off, and will probably be out for while stitched seal the wound. (More from NBC Sports: Rooney could be out 4 weeks)
• Ultimately, this was exactly the match we expected. United rebounds with a performance that flashes their attacking potential, while Fulham leaves empty handed from a match where they expected nothing.

Source: http://prosoccertalk.nbcsports.com/2012/08/25/offshore-drilling-england-manchester-united-3-fulham-2/related

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Bloom Where You're Planted: Update on Yi Hui

Source: http://charminfullbloom.blogspot.com/2012/08/update-on-yi-hui.html

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Almost toothless rodent survives on soft prey

CHEW over this evolutionary story. Rodents, which account for nearly 40 per cent of living mammal species, owe much of their success to their teeth - yet one rodent has got rid of most of its gnashers.

Paucidentomys vermidax was discovered in Indonesia last year by Jacob Esselstyn of McMaster University in Hamilton, Ontario, Canada, and his colleagues. It has no molars, and its incisors are shaped for gripping food rather than gnawing (Biology Letters, DOI: 10.1098/rsbl.2012.0574).

Esselstyn found that the rodent's stomach was packed with the remains of earthworms. He thinks it might live entirely on soft-bodied animals, which would explain why it would not need so many teeth.

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RIM exec says carriers are ?visibly enthusiastic? about BlackBerry 10

While it?s obviously way too soon to tell whether users will like RIM?s (RIMM) BlackBerry 10 operating system, one RIM executive says that wireless carriers are already big fans. AllThingsD?reports that RIM managing director of Canadian operations Andrew McLeod told reporters at a press briefing Thursday that there has been a ?tremendous? response to BlackBerry 10 from Canadian carriers, and he described some carrier executives as ?visibly positive and visibly enthusiastic? about the new operating system. McLeod went on to say that RIM is ?in the process of finalizing the software? and that the company now has enough confidence in the product to start showing it off more.

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Source: http://news.yahoo.com/rim-exec-says-carriers-visibly-enthusiastic-blackberry-10-183058721.html

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Slime Molds Help Show How Cancer Grows

As small islands of slime mold (black) grow toward each other, they meet other islands and join into a larger, single-celled slime mold (red). Image: Adrian Fessel et. al.

By Tim Wogan, ScienceNOW

Smarty-pants slime molds can solve mazes and produce diagrams similar to the Tokyo rail system?and now, scientists suggest, they may also be able to help treat cancer. Biophysicists in Germany and Singapore suggest that mathematical models based on slime mold behavior might lead to new ways to starve tumors of blood.

The slime mold Physarum polycephalum, usually found growing inside rotting logs, forages for food by extending a network of thin tendrils from its edge. Once the mold has found food, such as a piece of decaying vegetation or a microorganism, it grows over it and secretes digestive enzymes. P. polycephalum then constructs an elaborate network of interconnections between food sources, allowing it to shuttle nutrients around.

In 2010, mathematical biologist Toshiyuki Nakagaki, now at the Future University Hakodate in Japan, and his colleagues observed how this networking behavior might translate to efficient city planning; they placed the mold in a laboratory culture that also contained a scale model of the region around Tokyo, with food sources representing population centers. The slime mold?s tendrils, they found, produced interconnections strikingly similar to the layout of the Tokyo railway system.

But it?s the mold?s early growth, even before it forms those elaborate foraging networks, which might hold clues to understanding how tumors supply themselves with blood. Slime molds start as a collection of isolated spores; as they grow outward, the spores meet and fuse into islands. The islands send out tendrils that eventually meet other islands; when they meet, they fuse again, ultimately forming a large, single-celled organism that can now transport fluid throughout itself. There?s a mathematical term for this: The point at which separate networks, each with its own transport system, become interconnected enough to allow a fluid or some other substance to move freely between them is called the ?percolation transition.?

To construct a mathematical model of the percolation transition, Adrian Fessel, Hans-G?nther D?bereiner, and colleagues at the University of Bremen in Germany and the Mechanobiology Institute, Singapore studied the way that slime molds grow in the laboratory. Understanding how those connections form and when that transition occurs may have a practical application, D?bereiner says. To survive and grow, tumors need a blood supply; many highly invasive tumors can construct a completely new vascular system from tumor stem cells which grow, meet, and fuse before connecting to the healthy tissue?s blood supply. Since the process of connection is mathematically identical to the percolation transition in the slime mold, a mathematical model of the latter should be equally valid for both, he says.

As the mold tendrils grew toward each other and joined up, the researchers used network diagrams (like subway maps) to track the connections between tendrils. They recorded how many connections radiated out from each node to get a measurement of ?interconnectedness,? similar to the number of subway lines that serve a particular station. Writing in Physical Review Letters, the scientists found that the transition from multiple mold islands to an interconnected network?the percolation transition?always occurred when the nodes and lines fell into one particular, peculiar pattern. Regardless of how many overall nodes there were, what mattered was how many of them had exactly three emerging lines, how many had one emerging line, and how many nodes remained completely isolated. For one particular ratio of those three numbers, percolation transition always happened.

?The results are very interesting and novel,? says Nakagaki, who was not involved in the present work, ?and the analysis by means of a standard technique of percolation is clear and beautiful.?

Starving tumors of blood is a key way to attack cancers, so D?bereiner hopes that the researchers? insight into vascular network formation may one day lead to ways to inhibit the development of tumors? blood supplies and curb their growth. To demonstrate their model?s applicability to vascular growth, the researchers showed that they could reproduce the results of a 2003 laboratory study into the growth of vascular networks using their slime mold-derived mathematical model.

Although reproducing that 2003 study is a useful demonstration that their model is applicable beyond slime molds, D?bereiner points out that from a mathematical standpoint, such a demonstration is somewhat redundant. The two situations?slime mold growth and vascular network growth?are mathematically equivalent, he says, and so a model that works for one is required to work for the other. ?Even if we hadn?t done that experiment [with the vascular network] ? there is mathematically no way out!?

This story provided by ScienceNOW, the daily online news service of the journal Science.

Source: http://feeds.wired.com/~r/wiredscience/~3/tzipvzO5IeU/

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Video: Remnants of DC quake remain on anniversary

>>> it's been a year today since first word of the news we couldn't believe, the quake that rocked washington, d.c., the tourists are still seeing the after effects of the 5.8 earthquake. there is still netting under the ceiling of union station , scaffolding at the national cathedral spire and the washington monument is still closed. it could take another decade and $20 million more.

Source: http://video.msnbc.msn.com/nightly-news/48772183/

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It is estimated that over 40 million workers within the United states had to receive emergency medical treatment for workplace-related injuries inside the year 2003. This is a staggering quantity when one particular considers the efforts most companies have place into maintaining a protected workplace. In modern occasions, numerous companies have been discovered liable for injuries sustained in their locations of organization. There is a partnership that exists amongst workplace safety and profitability.

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Family Fresh Meals: Time to Vote: Pasta Recipes

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*And don't forget, for MOST weeks, the random number generator will be selecting the winner...but you never know when that number generator will break down and it will be left to the votes! So make sure to vote!)*
Sunday morning the winner of the gift card & Featured Recipe will be announced & new theme (Anything Goes) will begin, so make sure to check back.

Source: http://www.familyfreshmeals.com/2012/08/time-to-vote-pasta-recipes.html

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New insights into salt transport in the kidney

Public release date: 23-Aug-2012
[ | E-mail | Share ]

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres

Sodium chloride, better known as salt, is vital for the organism, and the kidneys play a crucial role in the regulation of sodium balance. However, the underlying mechanisms of sodium balance are not yet completely understood. Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Charit Universittsmedizin Berlin and the University of Kiel have now deciphered the function of a gene in the kidney and have thus gained new insights into this complex regulation process (PNAS Early Edition, doi/10.1073/pnas.1203834109)*.

In humans, the kidneys filter around 1700 liters of blood every day, of which 180 liters are collected as primary urine and ultimately one to two liters of urine are excreted. The kidneys thus wash toxic waste products out of the body, but retain some useful substances and reintroduce them into the body, thus simultaneously regulating the salt and water balance.

Molecular velcro

In the study just published by Dr. Tilman Breiderhoff, Prof. Thomas Willnow (both MDC), as well as Dr. Nina Himmerkus and Prof. Markus Bleich (both of the University of Kiel) and Dr. Dominik Mller (Charit) the focus is on the claudin-10 gene, which is expressed in a specific segment of the kidney, in Henle's loop. In the thick ascending limb of this loop, , a large part of the filtered sodium chloride, as well as calcium and magnesium are reabsorbed. The gene product under investigation, the claudin 10 protein, belongs to a family of proteins that connect the epithelial cells which cover the inner and outer surfaces of the body and stick them together like velcro. Claudins, however, also form pores, through which ions and substances are transported between the cells.

"If these transport processes are disturbed, this can lead to serious loss of function of the kidneys," Dr. Breiderhoff explained. As example he cited various human hereditary diseases in which either absorption of table salt (Bartter syndrome) or of calcium and magnesium (familial hypomagnesemia with hypercalciuria and nephrocalcinosis FHHNC) is disturbed. The second disease is characterized by a lack of magnesium in the blood and an excess of calcium in the urine, which leads to calcification of the kidneys. It is caused by mutations in one of two genes (claudin 16 or claudin 19), which also belong to the gene family of the claudins.

The researchers have now demonstrated in mice that the claudin-10 gene is involved in the reabsorption of salt in the kidney. If the gene in the kidney is deactivated, the reabsorption of sodium is impaired, but the reabsorption of calcium and magnesium is increased. The consequence is that the mice have elevated magnesium levels in the blood, and excess calcium is deposited in the kidney. Simultaneously, the urine volume is increased because the kidneys of the mice cannot reabsorb enough water, a sign that the recovery of salt is disturbed.

###

*Deletion of Cldn10 in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis Tilman Breiderhoffa,1, Nina Himmerkusb, Marchel Stuiverc, Kerim Mutigd, Constanze Willc, Iwan C. Meija, Sebastian Bachmannc, Markus Bleichb, Thomas E. Willnowa, and Dominik Mllerd,1

aMax Delbrck Center for Molecular Medicine, 13125 Berlin, Germany; bInstitute of Physiology, Christian Albrechts University of Kiel, 24098 Kiel, Germany; cDepartment of Pediatric Nephrology, Charit Universittsmedizin, 13353 Berlin, Germany; and dInstitute for Vegetative Anatomy, Charit Universittsmedizin, 10117 Berlin, Germany

A photo can be downloaded from the Internet at: http://www.mdc-berlin.de/en/index.html

PHYSIOLOGY

Contact:

Barbara Bachtler
Press Department
Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch in the Helmholtz Association
Robert-Rssle-Strae 10
13125 Berlin, Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de
http://www.mdc-berlin.de/

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 23-Aug-2012
[ | E-mail | Share ]

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres

Sodium chloride, better known as salt, is vital for the organism, and the kidneys play a crucial role in the regulation of sodium balance. However, the underlying mechanisms of sodium balance are not yet completely understood. Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Charit Universittsmedizin Berlin and the University of Kiel have now deciphered the function of a gene in the kidney and have thus gained new insights into this complex regulation process (PNAS Early Edition, doi/10.1073/pnas.1203834109)*.

In humans, the kidneys filter around 1700 liters of blood every day, of which 180 liters are collected as primary urine and ultimately one to two liters of urine are excreted. The kidneys thus wash toxic waste products out of the body, but retain some useful substances and reintroduce them into the body, thus simultaneously regulating the salt and water balance.

Molecular velcro

In the study just published by Dr. Tilman Breiderhoff, Prof. Thomas Willnow (both MDC), as well as Dr. Nina Himmerkus and Prof. Markus Bleich (both of the University of Kiel) and Dr. Dominik Mller (Charit) the focus is on the claudin-10 gene, which is expressed in a specific segment of the kidney, in Henle's loop. In the thick ascending limb of this loop, , a large part of the filtered sodium chloride, as well as calcium and magnesium are reabsorbed. The gene product under investigation, the claudin 10 protein, belongs to a family of proteins that connect the epithelial cells which cover the inner and outer surfaces of the body and stick them together like velcro. Claudins, however, also form pores, through which ions and substances are transported between the cells.

"If these transport processes are disturbed, this can lead to serious loss of function of the kidneys," Dr. Breiderhoff explained. As example he cited various human hereditary diseases in which either absorption of table salt (Bartter syndrome) or of calcium and magnesium (familial hypomagnesemia with hypercalciuria and nephrocalcinosis FHHNC) is disturbed. The second disease is characterized by a lack of magnesium in the blood and an excess of calcium in the urine, which leads to calcification of the kidneys. It is caused by mutations in one of two genes (claudin 16 or claudin 19), which also belong to the gene family of the claudins.

The researchers have now demonstrated in mice that the claudin-10 gene is involved in the reabsorption of salt in the kidney. If the gene in the kidney is deactivated, the reabsorption of sodium is impaired, but the reabsorption of calcium and magnesium is increased. The consequence is that the mice have elevated magnesium levels in the blood, and excess calcium is deposited in the kidney. Simultaneously, the urine volume is increased because the kidneys of the mice cannot reabsorb enough water, a sign that the recovery of salt is disturbed.

###

*Deletion of Cldn10 in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis Tilman Breiderhoffa,1, Nina Himmerkusb, Marchel Stuiverc, Kerim Mutigd, Constanze Willc, Iwan C. Meija, Sebastian Bachmannc, Markus Bleichb, Thomas E. Willnowa, and Dominik Mllerd,1

aMax Delbrck Center for Molecular Medicine, 13125 Berlin, Germany; bInstitute of Physiology, Christian Albrechts University of Kiel, 24098 Kiel, Germany; cDepartment of Pediatric Nephrology, Charit Universittsmedizin, 13353 Berlin, Germany; and dInstitute for Vegetative Anatomy, Charit Universittsmedizin, 10117 Berlin, Germany

A photo can be downloaded from the Internet at: http://www.mdc-berlin.de/en/index.html

PHYSIOLOGY

Contact:

Barbara Bachtler
Press Department
Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch in the Helmholtz Association
Robert-Rssle-Strae 10
13125 Berlin, Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de
http://www.mdc-berlin.de/

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-08/haog-nii082312.php

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The Oatmeal Hits Its $850,000 Goal To Fund A Tesla Museum In Less Than A Week

About a week after posting a call for donations to fund a Tesla Museum on Long Island, the goal has been surpassed by $20,000. Matthew Inman of The Oatmeal announced the plan last week in a post entitled "Let's Build a Goddamn Tesla Museum" and it looks like his dream - and ours - will come true.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/0hLDi8_bW2M/

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Commercial Real Estate Agents - Property Management Services And

Sorry, Readability was unable to parse this page for content.

Source: http://www.clickmyarticle.com/?p=49881

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New York Real Estate News: Real Estate Investing in Rehabs

Real estate investing in rehabs is a field of investment that is excellent for skilled and experienced investors and is not a good option for beginners. Real estate investors looking to rehab a house need to evaluate the site as well as the structural pattern of the house.

For the smart and proficient real estate investors, rehab real estate investing is one of the finest techniques that can bestow in profits beyond their imagination. Several real estate investors utilize real estate investing rehabs to figure their fortunes.

Such investors are constantly hunting for run down, overlooked, and unattractive estates for very minor margins. Further, they fix the estate, preserving the costs of repair as low as possible, repaint the estate, provide a renovation, and execute to sell the estate at an awesome price for huge marginal profits.

The evaluation of the site to rehab is done with thorough consideration to the type of vicinity in which the estate is located, shopping amenities as well as with the accessibility of transportation facilities in the vicinity.

Real estate investors need to possess an excellent concept of the local realty hoard, the present land value, with full experience in rehabbing, to review the requirement for fixing the estate. Further, investors are also required to have the capability to calculate the cost of rehabbing the estate, with the decision for rehabbing the estate by their own, or lending the job to someone else. Investors are advised to deem over every feature, for attempting to acquire the house at a greater profit, and work things out with very less cost price while trying to sell it for its present market value, or higher than that.

Further, the investors are also required to possess a fine concept about the latest patterns in colors and interior furnishings expenses as per the planned finances. This will aid in making the rehabbed house attractive to the promising buyers. But, the investors are advised to carry out the rehab procedure on their own, as this reduces the expense to almost 50% than what a contractor will charge for the same. It is an excellent situation, if the investor is trained proficiently to rehab the houses, as that investor is bound to have an apparent idea of the chores that are required to be conducted, along with the method to cover up the process at the lowest expense possible.

There are certain real estate investors who make prime money by investing in rehabbing commercial real estates, while others are professionals in rehabbing outdated houses, making big profits, opting for the estates located close to a lake or pond. There are certain other investors who focus on rehabbing condos in places where there is a comprehensive demand for condos.

Certain real estate investors rehab and sell off their estates at an excellent profit, and yet others rehab, refinance and lease the estate to acquire fine returns on those investments. For instance, there are certain investors who buy the homes for say $100,000, and rehab it for say $30,000 and sell it for around $200,000. Hence, the sky is the limit for skilled real estate investors investing in rehabs.

Charles W. Moore, a U.S. Army Veteran began Real Estate Investing in 2001. He's a Successful Investor, and Author of, "Million Dollar Rent To Own Real Estate Secrets Exposed." Get his Free Report on Rent To Own Real Estate Investing [http://www.Rent2OwnExposed.com] at: [http://www.Rent2OwnExposed.com] - Learn Real Estate Investing, Stocks Markets and Internet Marketing, visit: http://www.REIeBooks.com

Source: http://vprealestatenews.blogspot.com/2012/08/real-estate-investing-in-rehabs.html

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