>>>it's been a year today since first word of the news we couldn't believe, the quake that rocked washington, d.c., the tourists are still seeing the after effects of the 5.8 earthquake. there is still netting under the ceiling of
union station
, scaffolding at the
national cathedral
spire and the
washington monument
is still closed. it could take another decade and $20 million more.
It is estimated that over 40 million workers within the United states had to receive emergency medical treatment for workplace-related injuries inside the year 2003. This is a staggering quantity when one particular considers the efforts most companies have place into maintaining a protected workplace. In modern occasions, numerous companies have been discovered liable for injuries sustained in their locations of organization. There is a partnership that exists amongst workplace safety and profitability.
Every single company, especially those involved in industrial manufacturing, is consistently taking a look at approaches to continuously improve their products and processes. They recognize that their income are directly connected to the approaches and implies by which they create their items. Regrettably, also several businesses get caught up in drive for higher profits and are likely to allow workplace safety to become an afterthought.
The expenses connected with operating a sizable manufacturing facility in America are astounding. Workplace injuries location an enormous burden of expense and weakened productivity on a company. These injuries can be lowered with correct preparing and cautious focus to detail. Most workplace injuries are preventable. You will find several variables to consider, but sustaining a secure and tidy work location is one of the best techniques to prevent injury. Workers, also, have a responsibility in keeping themselves protected from harm.
Workplace injuries location a considerable burden on well being care providers and insurance coverage organizations. As companies continue to spend higher premiums for employee wellness care, among the only means accessible for expense recovery is to enhance the prices from the goods they create. This areas the burden of expense on the customer, and permits firms to ignore the root cause of their workplace injuries. The focus here appears to become on keeping a healthful partnership with shareholders, and not necessarily on sustaining a wholesome workforce.
It really is interesting to note that you will find record numbers of jobs, particularly inside the industrial sector, getting sent overseas. You can find several reasons to account for this. Probably the most substantial reasons is the fact that American organizations are able to shave their operating fees down to a fraction of their domestic charges, by capitalizing on cheaper labor in foreign markets. Foreign governments, eager for investment, are all as well prepared to accommodate the interests of massive western company. Far also typically, this comes at the expense of workplace safety.
If businesses desire to be profitable inside the long term, they want to reexamine their approach to workplace safety as well as the wellness of their workers. A lot of companies are sending jobs overseas, so that you can take advantage of low cost labor and relaxed labor laws. American companies can be both profitable and safety conscious. By means of directed education campaigns and preemptive arranging, workplace injuries can be reduced inside an important way. Bear in mind: a safe worker is really a satisfied worker, and a pleased worker is actually a productive worker.
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New insights into salt transport in the kidneyPublic release date: 23-Aug-2012 [ | E-mail | Share ]
Contact: bachtler@mdc-berlin.de bachtler@mdc-berlin.de 49-309-406-3896 Helmholtz Association of German Research Centres
Sodium chloride, better known as salt, is vital for the organism, and the kidneys play a crucial role in the regulation of sodium balance. However, the underlying mechanisms of sodium balance are not yet completely understood. Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Charit Universittsmedizin Berlin and the University of Kiel have now deciphered the function of a gene in the kidney and have thus gained new insights into this complex regulation process (PNAS Early Edition, doi/10.1073/pnas.1203834109)*.
In humans, the kidneys filter around 1700 liters of blood every day, of which 180 liters are collected as primary urine and ultimately one to two liters of urine are excreted. The kidneys thus wash toxic waste products out of the body, but retain some useful substances and reintroduce them into the body, thus simultaneously regulating the salt and water balance.
Molecular velcro
In the study just published by Dr. Tilman Breiderhoff, Prof. Thomas Willnow (both MDC), as well as Dr. Nina Himmerkus and Prof. Markus Bleich (both of the University of Kiel) and Dr. Dominik Mller (Charit) the focus is on the claudin-10 gene, which is expressed in a specific segment of the kidney, in Henle's loop. In the thick ascending limb of this loop, , a large part of the filtered sodium chloride, as well as calcium and magnesium are reabsorbed. The gene product under investigation, the claudin 10 protein, belongs to a family of proteins that connect the epithelial cells which cover the inner and outer surfaces of the body and stick them together like velcro. Claudins, however, also form pores, through which ions and substances are transported between the cells.
"If these transport processes are disturbed, this can lead to serious loss of function of the kidneys," Dr. Breiderhoff explained. As example he cited various human hereditary diseases in which either absorption of table salt (Bartter syndrome) or of calcium and magnesium (familial hypomagnesemia with hypercalciuria and nephrocalcinosis FHHNC) is disturbed. The second disease is characterized by a lack of magnesium in the blood and an excess of calcium in the urine, which leads to calcification of the kidneys. It is caused by mutations in one of two genes (claudin 16 or claudin 19), which also belong to the gene family of the claudins.
The researchers have now demonstrated in mice that the claudin-10 gene is involved in the reabsorption of salt in the kidney. If the gene in the kidney is deactivated, the reabsorption of sodium is impaired, but the reabsorption of calcium and magnesium is increased. The consequence is that the mice have elevated magnesium levels in the blood, and excess calcium is deposited in the kidney. Simultaneously, the urine volume is increased because the kidneys of the mice cannot reabsorb enough water, a sign that the recovery of salt is disturbed.
###
*Deletion of Cldn10 in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis
Tilman Breiderhoffa,1, Nina Himmerkusb, Marchel Stuiverc, Kerim Mutigd, Constanze Willc, Iwan C. Meija, Sebastian Bachmannc, Markus Bleichb, Thomas E. Willnowa, and Dominik Mllerd,1
aMax Delbrck Center for Molecular Medicine, 13125 Berlin, Germany; bInstitute of Physiology, Christian Albrechts University of Kiel, 24098 Kiel, Germany; cDepartment of Pediatric Nephrology, Charit Universittsmedizin, 13353 Berlin, Germany; and dInstitute for Vegetative Anatomy, Charit Universittsmedizin, 10117 Berlin, Germany
A photo can be downloaded from the Internet at:
http://www.mdc-berlin.de/en/index.html
PHYSIOLOGY
Contact:
Barbara Bachtler
Press Department
Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch
in the Helmholtz Association
Robert-Rssle-Strae 10
13125 Berlin, Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de
http://www.mdc-berlin.de/
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
New insights into salt transport in the kidneyPublic release date: 23-Aug-2012 [ | E-mail | Share ]
Contact: bachtler@mdc-berlin.de bachtler@mdc-berlin.de 49-309-406-3896 Helmholtz Association of German Research Centres
Sodium chloride, better known as salt, is vital for the organism, and the kidneys play a crucial role in the regulation of sodium balance. However, the underlying mechanisms of sodium balance are not yet completely understood. Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Charit Universittsmedizin Berlin and the University of Kiel have now deciphered the function of a gene in the kidney and have thus gained new insights into this complex regulation process (PNAS Early Edition, doi/10.1073/pnas.1203834109)*.
In humans, the kidneys filter around 1700 liters of blood every day, of which 180 liters are collected as primary urine and ultimately one to two liters of urine are excreted. The kidneys thus wash toxic waste products out of the body, but retain some useful substances and reintroduce them into the body, thus simultaneously regulating the salt and water balance.
Molecular velcro
In the study just published by Dr. Tilman Breiderhoff, Prof. Thomas Willnow (both MDC), as well as Dr. Nina Himmerkus and Prof. Markus Bleich (both of the University of Kiel) and Dr. Dominik Mller (Charit) the focus is on the claudin-10 gene, which is expressed in a specific segment of the kidney, in Henle's loop. In the thick ascending limb of this loop, , a large part of the filtered sodium chloride, as well as calcium and magnesium are reabsorbed. The gene product under investigation, the claudin 10 protein, belongs to a family of proteins that connect the epithelial cells which cover the inner and outer surfaces of the body and stick them together like velcro. Claudins, however, also form pores, through which ions and substances are transported between the cells.
"If these transport processes are disturbed, this can lead to serious loss of function of the kidneys," Dr. Breiderhoff explained. As example he cited various human hereditary diseases in which either absorption of table salt (Bartter syndrome) or of calcium and magnesium (familial hypomagnesemia with hypercalciuria and nephrocalcinosis FHHNC) is disturbed. The second disease is characterized by a lack of magnesium in the blood and an excess of calcium in the urine, which leads to calcification of the kidneys. It is caused by mutations in one of two genes (claudin 16 or claudin 19), which also belong to the gene family of the claudins.
The researchers have now demonstrated in mice that the claudin-10 gene is involved in the reabsorption of salt in the kidney. If the gene in the kidney is deactivated, the reabsorption of sodium is impaired, but the reabsorption of calcium and magnesium is increased. The consequence is that the mice have elevated magnesium levels in the blood, and excess calcium is deposited in the kidney. Simultaneously, the urine volume is increased because the kidneys of the mice cannot reabsorb enough water, a sign that the recovery of salt is disturbed.
###
*Deletion of Cldn10 in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis
Tilman Breiderhoffa,1, Nina Himmerkusb, Marchel Stuiverc, Kerim Mutigd, Constanze Willc, Iwan C. Meija, Sebastian Bachmannc, Markus Bleichb, Thomas E. Willnowa, and Dominik Mllerd,1
aMax Delbrck Center for Molecular Medicine, 13125 Berlin, Germany; bInstitute of Physiology, Christian Albrechts University of Kiel, 24098 Kiel, Germany; cDepartment of Pediatric Nephrology, Charit Universittsmedizin, 13353 Berlin, Germany; and dInstitute for Vegetative Anatomy, Charit Universittsmedizin, 10117 Berlin, Germany
A photo can be downloaded from the Internet at:
http://www.mdc-berlin.de/en/index.html
PHYSIOLOGY
Contact:
Barbara Bachtler
Press Department
Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch
in the Helmholtz Association
Robert-Rssle-Strae 10
13125 Berlin, Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de
http://www.mdc-berlin.de/
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
About a week after posting a call for donations to fund a Tesla Museum on Long Island, the goal has been surpassed by $20,000. Matthew Inman of The Oatmeal announced the plan last week in a post entitled "Let's Build a Goddamn Tesla Museum" and it looks like his dream - and ours - will come true.
Real estate investing in rehabs is a field of investment that is excellent for skilled and experienced investors and is not a good option for beginners. Real estate investors looking to rehab a house need to evaluate the site as well as the structural pattern of the house.
For the smart and proficient real estate investors, rehab real estate investing is one of the finest techniques that can bestow in profits beyond their imagination. Several real estate investors utilize real estate investing rehabs to figure their fortunes.
Such investors are constantly hunting for run down, overlooked, and unattractive estates for very minor margins. Further, they fix the estate, preserving the costs of repair as low as possible, repaint the estate, provide a renovation, and execute to sell the estate at an awesome price for huge marginal profits.
The evaluation of the site to rehab is done with thorough consideration to the type of vicinity in which the estate is located, shopping amenities as well as with the accessibility of transportation facilities in the vicinity.
Real estate investors need to possess an excellent concept of the local realty hoard, the present land value, with full experience in rehabbing, to review the requirement for fixing the estate. Further, investors are also required to have the capability to calculate the cost of rehabbing the estate, with the decision for rehabbing the estate by their own, or lending the job to someone else. Investors are advised to deem over every feature, for attempting to acquire the house at a greater profit, and work things out with very less cost price while trying to sell it for its present market value, or higher than that.
Further, the investors are also required to possess a fine concept about the latest patterns in colors and interior furnishings expenses as per the planned finances. This will aid in making the rehabbed house attractive to the promising buyers. But, the investors are advised to carry out the rehab procedure on their own, as this reduces the expense to almost 50% than what a contractor will charge for the same. It is an excellent situation, if the investor is trained proficiently to rehab the houses, as that investor is bound to have an apparent idea of the chores that are required to be conducted, along with the method to cover up the process at the lowest expense possible.
There are certain real estate investors who make prime money by investing in rehabbing commercial real estates, while others are professionals in rehabbing outdated houses, making big profits, opting for the estates located close to a lake or pond. There are certain other investors who focus on rehabbing condos in places where there is a comprehensive demand for condos.
Certain real estate investors rehab and sell off their estates at an excellent profit, and yet others rehab, refinance and lease the estate to acquire fine returns on those investments. For instance, there are certain investors who buy the homes for say $100,000, and rehab it for say $30,000 and sell it for around $200,000. Hence, the sky is the limit for skilled real estate investors investing in rehabs.
Charles W. Moore, a U.S. Army Veteran began Real Estate Investing in 2001. He's a Successful Investor, and Author of, "Million Dollar Rent To Own Real Estate Secrets Exposed." Get his Free Report on Rent To Own Real Estate Investing [http://www.Rent2OwnExposed.com] at: [http://www.Rent2OwnExposed.com] - Learn Real Estate Investing, Stocks Markets and Internet Marketing, visit: http://www.REIeBooks.com
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Public release date: 23-Aug-2012
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About a week after posting a call for donations to fund a Tesla Museum